Ezrin phosphorylation on tyrosine 477 regulates invasion and metastasis of breast cancer cells
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Summary
This study implicates a role of Y477 ezrin, which is phosphorylated by Src, in regulating local invasion and metastasis of breast carcinoma cells, and provides a clinically relevant model for assessing the Src/ezrin pathway as a potential prognostic/predictive marker or treatment target for invasive human breast cancer.
- Type
- article
- Published
- 2012-03-01
- Cited by
- 52
- References
- 50
- Access
- Open access
- OpenAlex
- https://openalex.org/W1601224168
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:602678
Keywords
Ezrin, Matrigel, Proto-oncogene tyrosine-protein kinase Src, Cancer research, Invadopodia
References
- Ezrin expression is related to poor prognosis in FIGO stage I endometrioid carcinomas
- Intense cytoplasmic ezrin immunoreactivity predicts poor survival in colorectal cancer.
- Factors Influencing Axillary Node Metastasis in Breast Cancer
- Ezrin as a prognostic indicator and its relationship to tumor characteristics in uveal malignant melanoma.
- Molecular Predictors of 3D Morphogenesis by Breast Cancer Cell Lines in 3D Culture
- Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by Integrin Blocking Antibodies
- Gene expression patterns associated with the metastatic phenotype in rodent and human tumors.
- The membrane cytoskeletal crosslinker ezrin is required for metastasis of breast carcinoma cells
- Capacity of adipose tissue to promote growth and metastasis of a murine mammary carcinoma: Effect of estrogen and progesterone
- Ezrin is essential for epithelial organization and villus morphogenesis in the developing intestine.
- Ezrin contains cytoskeleton and membrane binding domains accounting for its proposed role as a membrane-cytoskeletal linker
- Src Phosphorylates Ezrin at Tyrosine 477 and Induces a Phosphospecific Association between Ezrin and a Kelch-Repeat Protein Family Member*
- Ezrin, a membrane-cytoskeletal linking protein, is highly expressed in atypical endometrial hyperplasia and uterine endometrioid adenocarcinoma.
- Ezrin is key regulator of Src-induced malignant phenotype in three-dimensional environment
- The actin-cytoskeleton linker protein ezrin is regulated during osteosarcoma metastasis by PKC
- Co‐operative effect of c‐Src and ezrin in deregulation of cell–cell contacts and scattering of mammary carcinoma cells
- Abnormal ezrin localization is associated with clinicopathological features in invasive breast carcinomas
- Latent bone metastasis in breast cancer tied to Src-dependent survival signals
- Estradiol-induced ezrin overexpression in ovarian cancer: a new signaling domain for estrogen.
- The matrix reorganized: extracellular matrix remodeling and integrin signaling.
Cited by
- ERM proteins in cancer progression
- Scaffolding during the cell cycle by A-kinase anchoring proteins
- Markers for clinical outcome and therapy response in soft tissue sarcomas
- FLT3-driven redox-modulation of Ezrin regulates leukaemic cell migration
- Fer tyrosine kinase oligomer mediates and amplifies Src-induced tumor progression
- Classical cadherins control survival through the gp130/Stat3 axis.
- mRCC management: past, present and future
- Altered expression and phosphorylation of ezrin in rat ventral prostates during cadmium chloride-induced preneoplastic changes
- The expanding family of FERM proteins.
- Efficient tumorigenesis by mutation-induced failure to terminate microRNA-mediated adaptive hyperplasia.
- A novel role for ezrin in breast cancer angio/lymphangiogenesis
- Desmoglein 3: A Help or a Hindrance in Cancer Progression?
- Shotgun proteomics of archival triple‐negative breast cancer samples
- Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy
- Increased phosphorylation of ezrin is associated with the migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis.
- Ezrin overexpression predicts the poor prognosis of gastric adenocarcinoma
- Fascin and ezrin expression in Barrett's esophagus progression to adenocarcinoma
- Ezrin regulates focal adhesion and invadopodia dynamics by altering calpain activity to promote breast cancer cell invasion
- Regulation of ErbB2 localization and function in breast cancer cells by ERM proteins
- FoxM1 influences mouse hepatocellular carcinoma metastasis in vitro.
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- High levels of ezrin expressed by human pancreatic adenocarcinoma cell lines with high metastatic potential.
- Ezrin Ser66 phosphorylation regulates invasion and metastasis of esophageal squamous cell carcinoma cells by mediating filopodia formation.
- Ezrin promotes invasion and migration of the MG63 osteosarcoma cell
- Abstract 3940: Ezrin is a key regulator in Src-induced angiogenesis and lymphangiogenesis in breast cancer.
- Role of ezrin in breast cancer cells chemotaxis to CCL5
- Role for ezrin in breast cancer cell chemotaxis to CCL5.
- Ovarian epithelial carcinoma tyrosine phosphorylation, cell proliferation, and ezrin translocation are stimulated by interleukin 1α and epidermal growth factor