An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction.
Explore this paper's citation graph
Summary
The findings of this large-scale trial indicate that accelerated t-PA given with intravenous heparin provides a survival benefit over previous standard thrombolytic regimens.
- Type
- article
- Published
- 1993-09-02
- Cited by
- 3,873
- References
- 21
- Access
- Open access
- OpenAlex
- https://openalex.org/W1596397105
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20322138
Keywords
Medicine, Streptokinase, Myocardial infarction, Tissue plasminogen activator, Randomized controlled trial
References
- Myocardial revascularization after acute myocardial infarction.
- Recombinant tissue plasminogen activator
- Discrete sequential boundaries for clinical trials
- Improved thrombolysis with a modified dose regimen of recombinant tissue-type plasminogen activator.
- Improved thrombolysis in acute myocardial infarction with front-loaded administration of alteplase: results of the rt-PA-APSAC patency study (TAPS)
- Coronary arterial thrombolysis with combined infusion of recombinant tissue-type plasminogen activator and urokinase in patients with acute myocardial infarction.
- A Prospective, Randomized Trial Comparing Combination Half‐Dose Tissue‐Type Plasminogen Activator and Streptokinase With Full-Dose Tissue‐Type Plasminogen Activator
- Effect of early intravenous heparin on coronary patency, infarct size, and bleeding complications after alteplase thrombolysis: results of a randomised double blind European Cooperative Study Group trial.
- A multiple testing procedure for clinical trials.
- Randomized angiographic trial of recombinant tissue-type plasminogen activator (alteplase) in myocardial infarction. RAAMI Study Investigators.
- Which thrombolytic agent should one choose?
- Evaluation of Combination Thrombolytic Therapy and Timing of Cardiac Catheterization in Acute Myocardial Infarction: Results of Thrombolysis and Angioplasty in Myocardial Infarction–Phase5 Randomized Trial
- Illusion of Reperfusion Does Anyone Achieve Optimal Reperfusion During Acute Myocardial Infarction?
- Confronting the issues of patient safety and investigator conflict of interest in an international clinical trial of myocardial reperfusion. Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries (GUSTO) Steering Committee.
- Effect of heparin on coronary arterial patency after thrombolysis with tissue plasminogen activator in acute myocardial infarction.
- A comparison between heparin and low-dose aspirin as adjunctive therapy with tissue plasminogen activator for acute myocardial infarction. Heparin-Aspirin Reperfusion Trial (HART) Investigators.
- RANDOMISED TRIAL OF INTRAVENOUS STREPTOKINASE, ORAL ASPIRIN, BOTH, OR NEITHER AMONG 17 187 CASES OF SUSPECTED ACUTE MYOCARDIAL INFARCTION: ISIS-2
- Discrete Sequential Boundaries for Clinical Trials
- In-hospital mortality and clinical course of 20 891 patients with suspected acute myocardial infarction randomised between alteplase and streptokinase with or without heparin
Cited by
- A critical review of the efficacy and safety in the use of low-molecular-weight heparin in acute ST-elevation myocardial infarction: a Bayesan approach.
- Protocolo terapéutico del infarto de miocardio complicado
- Effects of streptokinase on reflow in rescue percutaneous coronary intervention
- Pharmacological Prevention of Reperfusion Injury in Acute Myocardial Infarction
- On the variability of covariate adjustment. experience with Koch's method for evaluating the absolute difference in proportions in randomized clinical trials.
- Have We Reached the Limit with Thrombolytic Therapy?
- Human monocyte subsets in coronary artery disease and myocardial infarction
- The physiological aspects of fibrinolysis.
- Accelerated TPA for treatment of prosthetic valve thrombosis
- Heparin and Streptokinase
- Atrial Fibrillation in the Setting of Acute Myocardial Infarction: The GUSTO-I Experience
- Randomized comparison of direct thrombin inhibition versus heparin in conjunction with fibrinolytic therapy for acute myocardial infarction: results from the GUSTO-IIb Trial. Global Use of Strategies to Open Occluded Coronary Arteries in Acute Coronary Syndromes (GUSTO-IIb) Investigators.
- Issues in extrapolating from clinical trials to clinical practice and outcomes.
- Comparison of thrombolytic therapies with mutant tPA (lanoteplase/SUN9216) and recombinant tPA (alteplase) for acute myocardial infarction.
- Patterns of practice for acute myocardial infarction in a population from ten countries
- Critical importance of myocardial salvage: relationship with the choice of reperfusion strategies.
- Plasminogen activator inhibitor-1 is a major determinant of arterial thrombolysis resistance.
- Hospital mortality from acute myocardial infarction has been modestly reduced after introduction of thrombolytics and aspirin: results from a new analytical approach. European Secondary Prevention Study Group.
- Electrocardiographic diagnosis of acute myocardial infarction in the presence of left bundle branch block.
- Visual Outcome after Treatment with Low-Dose Recombinant Tissue Plasminogen Activator or Hemodilution in Ischemic Central Retinal Vein Occlusion
Related papers
- Assessment of left ventricular function in a randomised study of intravenous anisoylated plasminogen streptokinase activator complex versus heparin in acute myocardial infarction. Preliminary results of the European Multicentre Study (Belgian Centres).
- Thrombolytic Therapy in Acute Myocardial Infarction Part II: 1997 Update
- Role of the clinical laboratory in monitoring fibrinolytic therapy of acute myocardial infarction.
- Efegatran sulfate as an adjunct to streptokinase versus heparin as an adjunct to tissue plasminogen activator in patients with acute myocardial infarction. ESCALAT Investigators.
- Survey of practicing cardiologists in Maryland on their choice of thrombolytic therapy for acute myocardial infarction.
- Thrombolysis utilisation in acute myocardial infarction in Bahrain.
- Thrombolytic Therapy: A Review of Its Use in Acute Myocardial Infarction
- Thrombolytic agents in acute myocardial infarction.