Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson's disease

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Summary

Observation that grafts of BDNF-producing fibroblasts protect against 6- OHDA-induced degeneration of SNpc dopaminergic neurons in the adult rat brain opens new perspectives for treatments aimed at the prevention of neurodegeneration in PD, using gene therapy and neurotrophic factors such as BDNF.

Type
article
Published
1995-12-01
Cited by
284
References
40
Access
Open access

Keywords

Dopaminergic, Neuroscience, Parkinson's disease, Neurotrophic factors, Genetically engineered

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