Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson's disease
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Summary
Observation that grafts of BDNF-producing fibroblasts protect against 6- OHDA-induced degeneration of SNpc dopaminergic neurons in the adult rat brain opens new perspectives for treatments aimed at the prevention of neurodegeneration in PD, using gene therapy and neurotrophic factors such as BDNF.
- Type
- article
- Published
- 1995-12-01
- Cited by
- 284
- References
- 40
- Access
- Open access
- OpenAlex
- https://openalex.org/W1590012920
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:33410040
Keywords
Dopaminergic, Neuroscience, Parkinson's disease, Neurotrophic factors, Genetically engineered
References
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- The rat brain in stereotaxic coordinates: Authors: George Paxinos & Charles Watson Academic Press Australia, 1982 Softback, 154 pages (including 71 plates), 35.00 Aust $
- Brain-derived neurotrophic factor (BDNF) prevents the degeneration of medial septal cholinergic neurons following fimbria transection
- The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents.
- Brain-derived neurotrophic factor administration protects basal forebrain cholinergic but not nigral dopaminergic neurons from degenerative changes after axotomy in the adult rat brain
- The neostriatal mosaic: II. Patch- and matrix-directed mesostriatal dopaminergic and non-dopaminergic systems
- Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat.
- BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra
- D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons.
- Neurotransmitters and neuromodulators in the basal ganglia.
- The therapeutic potential of neurotrophic factors in the treatment of Parkinson's disease.
- New insights into the cause of Parkinson's disease
- Brain-derived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve section
- Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neurotrophic factor but not neurotrophin 3.
- Sham transplantation protects against 6-hydroxydopamine-induced dopaminergic toxicity in rats: behavioral and morphological evidence.
- The oxidant stress hypothesis in Parkinson's disease: Evidence supporting it
- Molecular cloning of a human gene that is a member of the nerve growth factor family.
- Chronic intranigral administration of brain-derived neurotrophic factor produces striatal dopaminergic hypofunction in unlesioned adult rats and fails to attenuate the decline of striatal dopaminergic function following medial forebrain bundle transection.
Cited by
- Implanted BDNF-producing fibroblasts prevent neurotoxin-induced serotonergic denervation in the rat striatum.
- Gene therapy in Parkinson’s disease
- Changes in cytokines and neurotrophins in Parkinson's disease.
- PYM50028, a novel, orally active, nonpeptide neurotrophic factor inducer, prevents and reverses neuronal damage induced by MPP+ in mesencephalic neurons and by MPTP in a mouse model of Parkinson's disease
- Phenotype, compartmental organization and differential vulnerability of nigral dopaminergic neurons.
- Application of ex vivo gene therapy in the treatment of Parkinson's disease.
- Encapsulated neural transplants.
- Modulation of excessive neuronal activity by fibroblasts: Potential use in treatment of Parkinson's disease
- Molecular and Cellular Characterization of Dopamine Neuron Stimulating Peptides
- Approaches in the treatment of Parkinson's disease: A focus on stem cell-based therapies
- Experimental models of Parkinson's disease: insights from many models.
- Neurotrophic factors and neurodegenerative diseases: a delivery issue.
- Somatic gene therapy in animal models of Parkinson's disease.
- Interventions that Improve Body and Brain Bioenergetics for Parkinson's Disease Risk Reduction and Therapy
- Gene Therapy for Parkinson’s Disease
- Encapsulated cell implants as a novel treatment for Parkinson's disease.
- Infarctus cérébral et plasticité : focus sur le BDNF
- Role of Exercise and GDNF in an Animal Model of Parkinson's Disease: Implications for Neuroprotection
- Birth, life and death of dopaminergic neurons in the substantia nigra.
- Increased Survival of Dopaminergic Neurons in Striatal Grafts of Fetal Ventral Mesencephalic Cells Exposed to Neurotrophin-3 or Glial Cell Line-Derived Neurotrophic Factor
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