Terminally differentiated skeletal myotubes are not confined to G0 but can enter G1 upon growth factor stimulation.
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Summary
The results show that terminally differentiated cells are not confined to G0 but can partially reenter G1 in response to growth factors; they contribute to a much-needed definition of terminal differentiation.
- Type
- article
- Published
- 1996-08-01
- Cited by
- 62
- References
- 61
- OpenAlex
- https://openalex.org/W1566343530
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11690117
Keywords
Myogenesis, Biology, Cell cycle, Cell biology, Cellular differentiation
References
- Replicative senescence: the human fibroblast comes of age.
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- Induction of p21 (WAF-1/CIP1) during differentiation.
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- The biology of cell reproduction
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- Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis
- Transcriptional and posttranscriptional control of c-myc during myogenesis: its mRNA remains inducible in differentiated cells and does not suppress the differentiated phenotype
- Myogenesis: fusion, myosin synthesis, and the mitotic cycle.
- Plasticity of the differentiated state.
- Induction of proto-oncogene JUN/AP-1 by serum and TPA
- E2F: a link between the Rb tumor suppressor protein and viral oncoproteins.
- MyoD induces growth arrest independent of differentiation in normal and transformed cells.
- MyoD family: a paradigm for development?
- Multinucleated Muscle Fibres: Induction of DNA Synthesis and Mitosis by Polyoma Virus Infection
- Production and Characterization of Murine mAbs to the Extracellular Domain of Human Neu Oncogene Product GP185HER2
- Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-Cdk2 and cyclin D1-Cdk2 complexes.
- Inhibition of myogenic differentiation in proliferating myoblasts by cyclin D1-dependent kinase
- Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation.
- Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD
Cited by
- P21 and Retinoblastoma Protein Control the Absence of DNA Replication in Terminally Differentiated Muscle Cells
- Myc/Max/Mad in invertebrates: the evolution of the Max network.
- Np95 is regulated by E1A during mitotic reactivation of terminally differentiated cells and is essential for S phase entry
- Microrna-221 and Microrna-222 Modulate Differentiation and Maturation of Skeletal Muscle Cells
- Differentiation-related changes in the cell cycle traverse.
- Molecular and Cellular Basis of Regeneration and Tissue Repair
- A proteome-wide strategy reveals a novel mechanism of control of cell cycle progression through modulation of cyclin mRNA stability
- Functional studies in Rb regulation of skeletal myogenic program
- Purification of A Serum Factor That Triggers Cell Cycle Re-entry In Differentiated Newt Myotubes
- Rb is required for progression through myogenic differentiation but not maintenance of terminal differentiation
- Novel chemically defined approach to produce multipotent cells from terminally differentiated tissue syncytia.
- Myf5 expression in satellite cells and spindles in adult muscle is controlled by separate genetic elements.
- Regulation of Cyclin E Protein Levels through E2F-Mediated Inhibition of Degradation
- Retinoblastoma Protein and MyoD Function Together to Effect the Repression of Fra-1 and in Turn Cyclin D1 during Terminal Cell Cycle Arrest Associated with Myogenesis*
- Adenoviral delivery of E2F-1 directs cell cycle reentry and p53-independent apoptosis in postmitotic adult myocardium in vivo.
- Plasticity of Mammalian Myotubes Upon Stimulation with a Thrombin-activated Serum Factor
- Terminally differentiated muscle cells are defective in base excision DNA repair and hypersensitive to oxygen injury
- Inhibitors of tyrosine phosphatases and apoptosis reprogram lineage marked differentiated muscle to myogenic progenitor cells
- Cyclin D1 is a major target of miR-206 in cell differentiation and transformation
- Prolonged unloading of rat soleus muscle causes distinct adaptations of the gene profile
Related papers
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- Reconstitution of Cyclin D1-Associated Kinase Activity Drives Terminally Differentiated Cells into the Cell Cycle
- Expression of E1A in terminally differentiated muscle cells reactivates the cell cycle and suppresses tissue-specific genes by separable mechanisms
- Mitotic cycle reactivation in terminally differentiated cells by adenovirus infection
- Plasticity of the differentiated state.
- Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD
- Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation.
- Myogenesis: fusion, myosin synthesis, and the mitotic cycle.
- Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle
- Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle