Activation of the NLRP3 inflammasome by Mycobacterium tuberculosis is uncoupled from susceptibility to active tuberculosis
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Summary
During TB, Mycobacterium tuberculosis promotes NLRP3‐ and caspase‐1‐independent IL‐1β release in myeloid cells recruited to lung parenchyma and thus overcomesNLRP3 deficiency in vivo in experimental models.
- Type
- article
- Published
- 2012-02-01
- Cited by
- 172
- References
- 63
- Access
- Open access
- OpenAlex
- https://openalex.org/W1563133958
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205787870
Keywords
Inflammasome, Mycobacterium tuberculosis, Tuberculosis, Immunology, Biology
References
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- Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
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- Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation
- Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock.
Cited by
- Post-translational regulation of inflammasomes
- Etude des différents signaux d'activation de l'inflammasome dans les monocytes/macrophages : implication dans la réponse inflammatoire vis-à-vis des nanotubes de carbone et de Leishmania infantum
- Characterization of the immune response induced by non-pathogenic mycobacteria in macrophages and dendritic cells
- Mycobacterium tuberculosis and the human macrophage : shifting the balance through inflammasome activation
- Inflammasomes-dependent regulation of IL-1β secretion induced by the virulent Mycobacterium bovis Beijing strain in THP-1 macrophages
- Type I IFN signaling triggers immunopathology in tuberculosis-susceptible mice by modulating lung phagocyte dynamics
- Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1.
- Regulation and Function of the Nucleotide Binding Domain Leucine-Rich Repeat-Containing Receptor, Pyrin Domain-Containing-3 Inflammasome in Lung Disease.
- Activation and Regulation of Cellular Inflammasomes: Gaps in Our Knowledge for Central Nervous System Injury
- Cytokine and lipid mediator networks in tuberculosis
- Activation of an NLRP3 Inflammasome Restricts Mycobacterium kansasii Infection
- Antimicrobial inflammasomes: unified signalling against diverse bacterial pathogens.
- Cytosolic Access of Mycobacterium tuberculosis: Critical Impact of Phagosomal Acidification Control and Demonstration of Occurrence In Vivo
- Mycobacteria and the Intraphagosomal Environment: Take It With a Pinch of Salt(s)!
- Mycobacterium tuberculosis and the host cell inflammasome: a complex relationship
- Early clearance of Mycobacterium tuberculosis: a new frontier in prevention
- Susceptibility to Mycobacterium tuberculosis Infection in HIV-Positive Patients Is Associated With CARD8 Genetic Variant
- Characterization of NLRP12 during the In Vivo Host Immune Response to Klebsiella pneumoniae and Mycobacterium tuberculosis
- Propionibacterium acnes induces IL-1β secretion via the NLRP3 inflammasome in human monocytes
- Inflammation in tuberculosis: interactions, imbalances and interventions.
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