Carcinogenicity of 2',3'-dideoxycytidine in mice.
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Summary
There was a very high correlation between the internal dose of ddC and the incidence of thymic lymphoma in both mouse models and the potential carcinogenic risk should be considered in long-term treatment of HIV-positive patients, especially children and adolescent patients treated with ddC.
- Type
- article
- Published
- 1996-10-15
- Cited by
- 25
- References
- 36
- OpenAlex
- https://openalex.org/W1560488718
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23473340
Keywords
Lymphoma, Provirus, Biology, Spleen, Lymphocyte
References
- Apoptosis in normal development and cancer
- The heat stable antigen (mouse CD24) gene is differentially regulated but has a housekeeping promoter.
- Cellular metabolism of 2',3'-dideoxycytidine, a compound active against human immunodeficiency virus in vitro.
- Organization, distribution, and stability of endogenous ecotropic murine leukemia virus DNA sequences in chromosomes of Mus musculus
- Induction of thymic lymphoma in mice administered the dideoxynucleoside ddC.
- A MAJOR GENETIC LOCUS AFFECTING RESISTANCE TO INFECTION WITH MURINE LEUKEMIA VIRUSES
- Deoxynucleoside phosphorylating enzymes in monkey and human tissues show great similarities, while mouse deoxycytidine kinase has a different substrate specificity.
- Species differences in nucleotide pool levels of 2',3'-dideoxycytidine: a possible explanation for species-specific toxicity.
- Characterization of the murine heat‐stable antigen: An hematolymphoid differentiation antigen defined by the J11d, M1/69 and B2A2 antibodies
- Hematologic toxicity of AZT and ddC administered as single agents and in combination to rats and mice.
- Developmental toxicity of orally administered 2',3'-dideoxycytidine in mice.
- Dideoxycytidine permeation and salvage by mouse leukemia cells and human erythrocytes.
- Structure of endogenous murine leukemia virus DNA in mouse genomes.
- The susceptibility of inbred mice to the production of malignant thymoma by N-methyl-N-nitrosourea.
- Susceptibility to 1,3-butadiene-induced leukemogenesis correlates with endogenous ecotropic retroviral background in the mouse.
- Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotrophic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) by 2',3'-dideoxynucleosides.
- Reciprocal inhibition of mouse leukemia virus infection by Fv-1 allele cell extracts.
- Pharmacokinetics of 2‘,3’‐Dideoxycytidine in Patients with AIDS and Related Disorders
- Phase I studies of 2',3'-dideoxycytidine in severe human immunodeficiency virus infection as a single agent and alternating with zidovudine (AZT).
- Fluorescence flow cytometry in the study of lymphoid cell receptors.
Cited by
- Notch signalling in carcinogenesis : With special emphasis on T-cell lymphoma and colorectal cancer
- Lack of susceptibility of transgenic mice carrying the human c-Ha-ras proto-oncogene (rasH2 mice) to phenolphthalein in a 6-month carcinogenicity study.
- Analysis of p53 Tumor Suppressor Gene, H-ras Protooncogene and Proliferating Cell Nuclear Antigen (PCNA) in Squamous Cell Carcinomas of HRA/Skh Mice Following Exposure to 8-Methoxypsoralen (8-MOP) and UVA Radiation (PUVA Therapy)
- Multiorgan transplacental and neonatal carcinogenicity of 3'-azido-3'-deoxythymidine in mice.
- Genetic analysis of Raf1, Mdm2, c-Myc, Cdc25a and Cdc25b proto-oncogenes in 2',3'-dideoxycytidine- and 1,3-butadiene-induced lymphomas in B6C3F1 mice.
- Mutation analysis of the pRb pathway in 2',3'-dideoxycytidine- and 1, 3-butadiene-induced mouse lymphomas.
- Lack of susceptibility of heterozygous p53-knockout CBA and CIEA mice to phenolphthalein in a 6-month carcinogenicity study.
- Chemical-specific alterations in ras, p53, and beta-catenin genes in hemangiosarcomas from B6C3F1 mice exposed to o-nitrotoluene or riddelliine for 2 years.
- Possible mechanism on enhanced carcinogenesis of genotoxic carcinogens and unsolved mechanisms on lesser carcinogenic susceptibility to some carcinogens in rasH2 mice.
- Mutations of ras Protooncogenes and p53 Tumor Suppressor Gene in Cardiac Hemangiosarcomas from B6C3F1 Mice Exposed to 1,3-Butadiene for 2 Years
- Spinal cord damage in Zalcitabine maternally treated mice foetuses
- Bcl11b mutations identified in murine lymphomas increase the proliferation rate of hematopoietic progenitor cells
- Phenolphthalein Induces Thymic Lymphomas Accompanied by Loss of the p53 Wild Type Allele in Heterozygous p53-Deficient (±) Mice
- Predominant p53 G→A Transition Mutation and Enhanced Cell Proliferation in Uterine Sarcomas of CBA Mice Treated with 1,2-Dimethylhydrazine
- Notch1 is a frequent mutational target in chemically induced lymphoma in mouse
- Genetic risks of antiviral nucleoside analogues--a survey.
- Pharmacological and biological aspects of basic research on nucleoside-based reverse transcriptase inhibitors.
- With special emphasis on T-cell lymphoma and colorectal cancer
- Risk of cancer in children exposed to didanosine in utero
- Risk of cancer in children exposed to antiretroviral nucleoside analogues in utero: The french experience
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