Mechanism of chloride permeation in the cystic fibrosis transmembrane conductance regulator chloride channel
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Summary
A brief review of mechanistic insights about the molecular determinants of the CFTR Cl− channel pore region are summarized and incorporated into a simple cartoon model depicting the interactions between the channel and Cl− ions that are important for ion translocation.
- Type
- review
- Published
- 2006-01-01
- Cited by
- 118
- References
- 57
- OpenAlex
- https://openalex.org/W1559483365
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:37254079
Keywords
Cystic fibrosis transmembrane conductance regulator, Permeation, Chloride channel, Chemistry, Ion
References
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- Mechanism of anion permeation through channels gated by glycine and gamma‐aminobutyric acid in mouse cultured spinal neurones.
- The E. coli BtuCD Structure: A Framework for ABC Transporter Architecture and Mechanism
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- Disulphonic stilbene block of cystic fibrosis transmembrane conductance regulator Cl‐ channels expressed in a mammalian cell line and its regulation by a critical pore residue.
- Non‐pore lining amino acid side chains influence anion selectivity of the human CFTR Cl− channel expressed in mammalian cell lines
- Gating the Selectivity Filter in ClC Chloride Channels
- Structural basis for ion conduction and gating in ClC chloride channels
- Cystic fibrosis: The ‘bicarbonate before chloride’ hypothesis
- Direct Comparison of NPPB and DPC as Probes of CFTR Expressed in Xenopus Oocytes
- Relationship between anion binding and anion permeability revealed by mutagenesis within the cystic fibrosis transmembrane conductance regulator chloride channel pore
- Multi-ion pore behaviour in the CFTR chloride channel
- Bicarbonate conductance and pH regulatory capability of cystic fibrosis transmembrane conductance regulator.
- Function of Xenopus Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Cl− Channels and Use of Human-Xenopus Chimeras to Investigate the Pore Properties of CFTR*
Cited by
- Cysteine‐independent inhibition of the CFTR chloride channel by the cysteine‐reactive reagent sodium (2‐sulphonatoethyl) methanethiosulphonate
- Structural and functional interaction between domains in CFTR
- Fonction de CFTR dans les processus de réparation de l’épithélium des voies aériennes et développement de nouvelles stratégies thérapeutiques en fibrose kystique
- The physiology of anion transport: tales of the bizarre and unexpected
- Emerging role of cystic fibrosis transmembrane conductance regulator as an epigenetic regulator: linking environmental cues to microRNAs
- Stoichiometry and novel gating mechanism within the cystic fibrosis transmembrane conductance regulator channel
- Conformational changes opening and closing the CFTR chloride channel: insights from cysteine scanning mutagenesis.
- Novel Residues Lining the CFTR Chloride Channel Pore Identified by Functional Modification of Introduced Cysteines
- Rigid-rod anion-pi slides for multiion hopping across lipid bilayers.
- Cystic fibrosis: insight into CFTR pathophysiology and pharmacotherapy.
- The search for a common structural moiety among selected pharmacological correctors of the mutant CFTR chloride channel.
- Oxalate in renal stone disease: the terminal metabolite that just won't go away
- Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening
- State-dependent Access of Anions to the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Pore*
- Functional architecture of the CFTR chloride channel
- Understanding how cystic fibrosis mutations disrupt CFTR function: from single molecules to animal models.
- Molecular modelling approaches for cystic fibrosis transmembrane conductance regulator studies.
- N‐terminal CFTR missense variants severely affect the behavior of the CFTR chloride channel
- The electro-oculogram.
- Regulation of conductance by the number of fixed positive charges in the intracellular vestibule of the CFTR chloride channel pore
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- Effect of deleting the R domain on CFTR-generated chloride channels.
- New paradigms of CFTR chloride channel regulation
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- Defective Epithelial Chloride Transport in a Gene-Targeted Mouse Model of Cystic Fibrosis
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