CD8+ T-cell receptor bias and immundominance in HIV-1 infection
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Summary
An extensive analysis of CD8+ T cell responses restricted by a single HLA class I molecule provides important insights into a potential link between shared TCR recruitment, immunodominance, and antiviral efficacy in a major human infection.
- Type
- article
- Published
- 2015-04-24
- Cited by
- 35
- References
- 93
- Access
- Open access
- OpenAlex
- https://openalex.org/W1544638309
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20693208
Keywords
Immunodominance, Epitope, Biology, Immunology, Virology
References
- Germline-encoded amino acids in the αβ T cell receptor control thymic selection
- Absence of Tapasin Alters Immunodominance against a Lymphocytic Choriomeningitis Virus Polytope
- Unbiased molecular analysis of T cell receptor expression using template-switch anchored RT-PCR
- Selection of T Cell Clones Expressing High-Affinity Public TCRs within Human Cytomegalovirus-Specific CD8 T Cell Responses1
- Heterogeneity in HIV Suppression by CD8 T Cells from HIV Controllers: Association with Gag-Specific CD8 T Cell Responses1
- The role of naïve T cell precursor frequency and recruitment in dictating immune response magnitude
- Immunodominance of HLA-A2-Restricted Hepatitis C Virus-Specific CD8+ T Cell Responses Is Linked to Naïve-Precursor Frequency
- Definition of the viral targets of protective HIV-1-specific T cell responses
- Structural determinants of T-cell receptor bias in immunity
- HLA and AIDS: a cautionary tale.
- T Cell Receptor Clonotype Influences Epitope Hierarchy in the CD8+ T Cell Response to Respiratory Syncytial Virus Infection*
- Public clonotype usage identifies protective Gag-specific CD8+ T cell responses in SIV infection
- CD8+ T cell efficacy in vaccination and disease
- The molecular basis for public T-cell responses?
- Complex T-Cell Receptor Repertoire Dynamics Underlie the CD8+ T-Cell Response to HIV-1
- The stoichiometry of Gag protein in HIV-1
- T cell receptor recognition motifs govern immune escape patterns in acute SIV infection.
- Role of Transmitted Gag CTL Polymorphisms in Defining Replicative Capacity and Early HIV-1 Pathogenesis
- Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection
- Functional implications of T cell receptor diversity
Cited by
- Pol-Driven Replicative Capacity Impacts Disease Progression in HIV-1 Subtype C Infection
- Deciphering the human immunome
- Role of HLA Adaptation in HIV Evolution
- TCR clonotypes: molecular determinants of T-cell efficacy against HIV.
- Public T cell receptors confer high-avidity CD4 responses to HIV controllers.
- Impact of Pre-adapted HIV Transmission
- T cell receptor repertoires of immunodominant CD8 T cell responses to Theileria parva
- Dynamics of virus and immune response in multi-epitope network
- Protective HLA class I alleles : investigation of viral control and lack of control in chronic HIV-1 subtype C infection.
- T Cell Receptor Profiling in Type 1 Diabetes
- The Mutation-Associated Neoantigen Functional Expansion of Specific T cells (MANAFEST) assay: a sensitive platform for monitoring antitumor immunity
- High diversity, turnover, and structural constraints characterize TCR α and β repertoire selection
- Dual HLA B*42 and B*81-reactive T cell receptors recognize more diverse HIV-1 Gag escape variants
- Major TCR Repertoire Perturbation by Immunodominant HLA-B*44:03-Restricted CMV-Specific T Cells
- Dimorphism in the T-cell receptor constant region affects T-cell function, phenotype and HIV outcome.
- CDR3α drives selection of the immunodominant Epstein Barr virus (EBV) BRLF1-specific CD8 T cell receptor repertoire in primary infection
- Epstein Barr virus epitope/MHC interaction combined with convergent recombination drive selection of diverse T cell receptor α and β repertoires
- A mechanistic investigation of T cell receptor-mediated HIV control
- Epstein-Barr Virus Epitope–Major Histocompatibility Complex Interaction Combined with Convergent Recombination Drives Selection of Diverse T Cell Receptor α and β Repertoires
- Non synonymous substitutions in HIV-1 GAG are frequent in epitopes outside the major hydrophobic region and associated with subtype differences
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