Dopaminergic Role in Stimulant-Induced Wakefulness
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Summary
D dopamine transporters play an important role in sleep regulation and are necessary for the specific wake-promoting action of amphetamines and modafinil.
- Type
- article
- Published
- 2001-03-01
- Cited by
- 728
- References
- 57
- Access
- Open access
- OpenAlex
- https://openalex.org/W1538619854
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9947754
Keywords
Modafinil, Dopamine transporter, Wakefulness, Dopamine, Dopaminergic
References
- Increased dopaminergic transmission mediates the wake-promoting effects of CNS stimulants.
- Mesocortical dopamine neurons: rapid transmitter turnover compared to other brain catecholamine systems.
- Modafinil binds to the dopamine uptake carrier site with low affinity.
- Stimulants, neurochemical, behavioral, and clinical perspectives
- Mice lacking the norepinephrine transporter are supersensitive to psychostimulants
- A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains
- Brainstem Control of Wakefulness and Sleep
- Histaminergic descending inputs to the mesopontine tegmentum and their role in the control of cortical activation and wakefulness in the cat
- Quantitative Trait Loci Affecting Methamphetamine Responses in BXD Recombinant Inbred Mouse Strains
- Modafinil induces wakefulness without intensifying motor activity or subsequent rebound hypersomnolence in the rat.
- Behavioral correlates of dopaminergic unit activity in freely moving cats.
- Confirmation of association between attention deficit hyperactivity disorder and a dopamine transporter polymorphism
- Activity of mesencephalic dopamine and non-dopamine neurons across stages of sleep and walking in the rat.
- Central alpha 1-adrenergic stimulation in relation to the behaviour stimulating effect of modafinil; studies with experimental animals.
- Behavioral properties of GBR 12909, GBR 13069 and GBR 13098: specific inhibitors of dopamine uptake.
- Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter.
- Implication of dopaminergic mechanisms in the wake-promoting effects of amphetamine: a study of D- and L-derivatives in canine narcolepsy.
- The effect of lesions of catecholamine-containing neurons upon monoamine content of the brain and EEG and behavioral waking in the cat.
- Pharmacological aspects of human and canine narcolepsy.
- Non-rapid eye movement sleep is suppressed in transgenic mice with a deficiency in the somatotropic system.
Cited by
- Involvement of dopamine receptors in cocaine-induced genital reflexes after paradoxical sleep deprivation.
- Rebound hypersomnolence, stimulant abuse, and DAT-mediated dopamine release.
- Daytime Alertness in Parkinson’s Disease: Potentially Dose-Dependent, Divergent Effects by Drug Class
- Differences in the neurochemical and behavioural profiles of lisdexamfetamine methylphenidate and modafinil revealed by simultaneous dual-probe microdialysis and locomotor activity measurements in freely-moving rats
- Impact of Astroglial Connexins on Modafinil Pharmacological Properties.
- VTA dopaminergic neurons regulate ethologically relevant sleep–wake behaviors
- Agomelatine's effect on circadian locomotor rhythm alteration and depressive-like behavior in 6-OHDA lesioned rats.
- Extent and Health Consequences of Chronic Sleep Loss and Sleep Disorders
- Regulation of arousal by adenosine A1 and A2A receptors in the prefrontal cortex of C57BL/6J mouse
- Cognitive enhancing effects of modafinil in healthy volunteers
- Dérégulation de la dopamine et maladies du repos : maladie de Willis-Ekbom et Maladie de Parkinson
- Warfighter Sustainability: Maximizing Human Performance in Hostile Environments
- Neuropharmacology of Sleep and Wakefulness: 2012 Update
- Effect of modafinil on cerebral blood flow in narcolepsy patients.
- Brain circuits determine destiny in depression: a novel approach to the psychopharmacology of wakefulness, fatigue, and executive dysfunction in major depressive disorder.
- Evaluation of Modafinil in Preclinical Behavioral Assays of Abuse Liability
- Modafinil for the treatment of daytime sleepiness in Parkinson's disease: a double-blind, randomized, crossover, placebo-controlled polygraphic trial.
- A Comparison of the Efficacy of Modafinil and Dextroamphetamine as Alertness Promoting Agents in Aviators Performing Extended Operations
- The enhancement and impairment of learning by stimulants
- Approved and Investigational Uses of Modafinil
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