Inhibition of the transient receptor potential cation channel TRPM2 by 2‐aminoethoxydiphenyl borate (2‐APB)
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Summary
Transient receptor potential melastatin 2 is a non‐selective Ca2+‐permeable cation channel and is known to be activated by adenosine 5′‐diphosphoribose (ADP‐ribose) and hydrogen peroxide.
- Type
- article
- Published
- 2008-03-01
- Cited by
- 233
- References
- 29
- Access
- Open access
- OpenAlex
- https://openalex.org/W1534752717
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10339228
Keywords
TRPM2, Transient receptor potential channel, Chemistry, Flufenamic acid, Biochemistry
References
- Inhibition of TRPM2 cation channels by N‐(p‐amylcinnamoyl)anthranilic acid
- Block of TRPC5 channels by 2‐aminoethoxydiphenyl borate: a differential, extracellular and voltage‐dependent effect
- 2-Aminoethoxydiphenyl borate directly inhibits store-operated calcium entry channels in human platelets.
- 2-Aminoethoxydiphenyl Borate Is a Common Activator of TRPV1, TRPV2, and TRPV3*
- TRPM2 activation by cyclic ADP‐ribose at body temperature is involved in insulin secretion
- Requirement of the inositol trisphosphate receptor for activation of store-operated Ca2+ channels.
- Connexin36 and pancreatic beta-cell functions.
- ISOLATION OF RAT PANCREATIC ISLETS BY DUCTAL INJECTION OF COLLAGENASE1
- Signaling microdomains define the specificity of receptor-mediated InsP(3) pathways in neurons.
- Flufenamic acid is a pH-dependent antagonist of TRPM2 channels.
- 2-Aminoethoxydiphenyl borate inhibits phototransduction and blocks voltage-gated potassium channels in Limulus ventral photoreceptors.
- TRPV3 and TRPV4 Mediate Warmth-evoked Currents in Primary Mouse Keratinocytes*
- 2APB, 2-aminoethoxydiphenyl borate, a membrane-penetrable modulator of Ins(1,4,5)P3-induced Ca2+ release.
- TRPV1 and the gut: from a tasty receptor for a painful vanilloid to a key player in hyperalgesia.
- TRP channels as cellular sensors
- Functional Characterization of Homo- and Heteromeric Channel Kinases TRPM6 and TRPM7
- International Union of Pharmacology. XLIX. Nomenclature and Structure-Function Relationships of Transient Receptor Potential Channels
- From chills to chilis: mechanisms for thermosensation and chemesthesis via thermoTRPs.
- The cloned capsaicin receptor integrates multiple pain-producing stimuli.
- Discovery of SB-705498: a potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development.
Cited by
- Pharmacology of transient receptor potential melastatin channels in the vasculature
- Redox signal-mediated sensitization of transient receptor potential melastatin 2 (TRPM2) to temperature affects macrophage functions
- Calclium-calmodulin regulation of TRPM2 currents
- Transient receptor potential cation channels in pancreatic β cells.
- Synthetic modulators of TRP channel activity.
- STIM1 mediates multiple signalling pathways in neuronal growth cones
- Enhanced cytotoxicity in triple-negative and estrogen receptor-positive breast adenocarcinoma cells due to inhibition of the transient receptor potential melastatin-2 channel
- Advanced glycation end products (AGEs) activate mast cells
- Transient receptor potential (TRP) channels: a clinical perspective
- Ca2+‐dependent induction of TRPM2 currents in hippocampal neurons
- Vanilloid and Melastatin Transient Receptor Potential Channels in Vascular Smooth Muscle
- Hydrogen peroxide modulates synaptic transmission in ventral horn neurons of the rat spinal cord
- Pharmacological comparison of novel synthetic fenamate analogues with econazole and 2‐APB on the inhibition of TRPM2 channels
- H2O2-induced Ca2+ influx and its inhibition by N-(p-amylcinnamoyl) anthranilic acid in the β-cells: involvement of TRPM2 channels
- Oxidative stress-modulated TRPM ion channels in cell dysfunction and pathological conditions in humans.
- Role of an N-Terminal Splice Segment in the Activation of the Cation Channel TRPM2 by ADP-Ribose and Hydrogen Peroxide
- Aminoethoxydiphenyl Borate and Flufenamic Acid Inhibit Ca2+ Influx Through TRPM2 Channels in Rat Dorsal Root Ganglion Neurons Activated by ADP-Ribose and Rotenone
- TRPM2 Cation Channels, Oxidative Stress and Neurological Diseases: Where Are We Now?
- THE ROLE OF TRPM2 IN HYDROGEN PEROXIDE-INDUCED EXPRESSION OF INFLAMMATORY CYTOKINE AND CHEMOKINE IN RAT TRIGEMINAL GANGLIA
- Sex Differences in Neuroprotection Provided by Inhibition of TRPM2 Channels following Experimental Stroke
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