Levodopa and the progression of Parkinson's disease.
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Summary
The clinical data suggest that levodopa either slows the progression of Parkinson's disease or has a prolonged effect on the symptoms of the disease, and the neuroimaging data suggest either thatlevodopa accelerates the loss of nigrostriatal dopamine nerve terminals or that its pharmacologic effects modify the dopamine transporter.
- Type
- article
- Published
- 2004-12-09
- Cited by
- 1,828
- References
- 32
- Access
- Open access
- OpenAlex
- https://openalex.org/W1533056363
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23705324
Keywords
Levodopa, Medicine, Parkinsonism, Placebo, Carbidopa
References
- Levodopa-Induced Neurotoxicity
- Is There a Rationale for Neuroprotection Against Dopamine Toxicity in Parkinson's Disease?
- Neuroleptic malignant syndrome in advanced Parkinson's disease
- Recent Developments in Parkinson's Disease
- Is levodopa toxic to human substantia nigra?
- Time course of nigrostriatal degeneration in parkinson's disease
- Reproducibility and Effect of Levodopa on Dopamine Transporter Function Measurements: A [18F]CFT PET Study
- Decreased single‐photon emission computed tomographic 123Iβ‐CIT striatal uptake correlates with symptom severity in parkinson's disease
- Chronic levodopa is not toxic for remaining dopamine neurons, but instead promotes their recovery, in rats with moderate nigrostriatal lesions
- Levodopa: Is toxicity a myth?
- Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL‐PET study
- Glia protect fetal midbrain dopamine neurons in culture from L-DOPA toxicity through multiple mechanisms
- Time course of loss of clinical benefit following withdrawal of levodopa/carbidopa and bromocriptine in early Parkinson's disease
- Preservation of the substanitia nigra and locus coeruleus in a patient receiving levodopa (2 kg) plus decarboxylase inhibitor over a four‐year period
- Quantitative description of loss of clinical benefit following withdrawal of levodopa–carbidopa and bromocriptine in early Parkinson's disease
- The effect of deprenyl and levodopa on the progression of Parkinson's disease
- Parkinsonism
- Is levodopa toxic?
- Neurotrophic Effects of l‐DOPA in Postnatal Midbrain Dopamine Neuron/Cortical Astrocyte Cocultures
- A neuroleptic malignantlike syndrome due to levodopa therapy withdrawal.
Cited by
- Novel MAO-B inhibitors: potential therapeutic use of the selective MAO-B inhibitor PF9601N in Parkinson's disease.
- Treatment should not be initiated too soon in Parkinson's disease
- Role of adenosine A2A receptors in parkinsonian motor impairment and l-DOPA-induced motor complications.
- Assessment of Parkinson's disease with imaging.
- Behandlungs- und Versorgungsstrategien bei Alzheimer und verwandten Demenzen
- Clinical neuroprotection in Parkinson's disease - still waiting for the breakthrough.
- Calcium‐permeable AMPA receptors are involved in the induction and expression of l‐DOPA‐induced dyskinesia in Parkinson’s disease
- Levodopa: back to the future
- Progression and prognostic factors of motor impairment, disability and quality of life in newly diagnosed Parkinson's disease
- Bayesian Quantitative Disease–Drug–Trial Models for Parkinson’s Disease to Guide Early Drug Development
- The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the Non-Motor Symptoms of Parkinson's Disease
- Putting the efficacy of psychiatric and general medicine medication into perspective: review of meta-analyses
- How to treat Parkinson's disease in 2013.
- Effects of l-DOPA on striatal iodine-123-FP-CIT binding and behavioral parameters in the rat
- The Nature of Progression in Parkinson’s Disease: An Application of Non-Linear, Multivariate, Longitudinal Random Effects Modelling
- Dopamine heteroreceptor complexes as therapeutic targets in Parkinson’s disease
- Integrative Frequency Power of EEG Correlates with Progression of Mild Cognitive Impairment to Dementia in Parkinson’s Disease
- Role of the atypical vesicular glutamate transporter VGLUT3 in l-DOPA-induced dyskinesia.
- Clinical characteristics of fatigued Parkinson’s patients and the response to dopaminergic treatment
- Minimal clinically important differences for the experiences of daily living parts of movement disorder society–sponsored unified Parkinson's disease rating scale
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