The role of superoxide in the destruction of erythrocyte targets by human neutrophils.
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Summary
It is proposed that neutrophil-derived O2.- oxidizes oxyhemoglobin to generate methemoglobin and H2O2 which interact to form a cytotoxic complex capable of hemolyzing the erythrocyte target.
- Type
- article
- Published
- 1980-10-25
- Cited by
- 130
- References
- 0
- Access
- Open access
- OpenAlex
- https://openalex.org/W1531120019
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:44995596
Keywords
Superoxide, Neutrophile, Chemistry, Microbiology, Granulocyte
References
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- Redox State Of Erythrocyte Peroxiredoxin 2 During Oxidative Stress And Its Effect On Membrane Binding
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- Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions.
- In vitro effects of in vivo activated leukocytes on RBC filterability and lipid peroxidation
- Adenosine transport, erythrocyte deformability and microvascular dysfunction: An unrecognized potential role for dipyridamole therapy
- Human polymorphonuclear leukocyte-mediated cytotoxicity against varicella-zoster virus-infected fibroblasts
- Activated granulocyte induced alterations in red blood cells and protection by antioxidant enzymes
- Lung cell oxidant injury. Enhancement of polymorphonuclear leukocyte-mediated cytotoxicity in lung cells exposed to sustained in vitro hyperoxia.
- Glutathione metabolism as a determinant of therapeutic efficacy: a review.
- Exposure of human erythrocytes to oxygen radicals causes loss of deformability, increased osmotic fragility, lipid peroxidation and protein degradation
- Kinetics and site specificity of hydroperoxide-induced oxidative damage in red blood cells.
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