Combination therapy of erythropoietin, hydroxyurea, and clotrimazole in a beta thalassemic mouse: a model for human therapy.
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Summary
It is suggested that CLT not only inhibits erythrocyte dehydration, but also potentiates the erythropoietic and cellular survival responses to r-HuEPO and HU.
- Type
- article
- Published
- 1996-02-01
- Cited by
- 47
- References
- 52
- Access
- Open access
- OpenAlex
- https://openalex.org/W1529857030
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19134243
Keywords
Hematocrit, Erythropoietin, Hemoglobin, Red blood cell, Internal medicine
References
- Retrovirus-mediated transfer of the erythropoietin gene in hematopoietic cells improves the erythrocyte phenotype in murine beta-thalassemia.
- Calcium transport and ultrastructure of red cells in beta-thalassemia intermedia.
- Oxidative damage and erythrocyte membrane transport abnormalities in thalassemias.
- Globin-chain specificity of oxidation-induced changes in red blood cell membrane properties.
- Hemoglobin variants and activity of the (K+Cl-) cotransport system in human erythrocytes.
- Cellular and membrane properties of alpha and beta thalassemic erythrocytes are different: implication for differences in clinical manifestations.
- Increased mouse minor hemoglobin during erythroid stress: a model for hemoglobin regulation.
- High affinity inhibition of Ca(2+)-dependent K+ channels by cytochrome P-450 inhibitors.
- Inhibition of voltage‐gated Ca2+ entry into GH3 and chromaffin cells by imidazole antimycotics and other cytochrome P450 blockers
- Inhibitors of cytochrome P-450-dependent arachidonic acid metabolism.
- The function of calcium in the potassium permeability of human erythrocytes.
- Reversible deformation-dependent erythrocyte cation leak. Extreme sensitivity conferred by minimal peroxidation.
- Thalassemia: the consequences of unbalanced hemoglobin synthesis.
- Electrophoretically detected germinal mutations induced in the mouse by ethylnitrosourea.
- Evidence for a direct reticulocyte origin of dense red cells in sickle cell anemia.
- Regulation of erythrocyte cation and water content in sickle cell anemia.
- Clotrimazole inhibits cell proliferation in vitro and in vivo
- Induction of a Ca(2+)-activated K+ channel in human erythrocytes by mechanical stress.
- Structure-activity relationships in the induction of hepatic microsomal cytochrome P450 by clotrimazole and its structurally related compounds in rats.
- Increased erythrocyte cation permeability in thalassemia and conditions of marrow stress.
Cited by
- Dietary magnesium supplementation ameliorates anemia in a mouse model of beta-thalassemia.
- Meta-analysis on effectiveness of hydroxyurea to treat transfusion-dependent beta-thalassemia
- Sickle Cell Disease: Present and Future Treatment
- Cluster of erythrocyte band 3: a potential molecular target of exhaustive exercise-induced dysfunction of erythrocyte deformability.
- Deferiprone therapy in homozygous human beta-thalassemia removes erythrocyte membrane free iron and reduces KCl cotransport activity.
- Functional significance of the intermediate conductance Ca2+-activated K+ channel for the short-term survival of injured erythrocytes
- Induction of gamma-globin mRNA, erythroid differentiation and apoptosis in UVA-irradiated human erythroid cells in the presence of furocumarin derivatives.
- Blood Transfusion in Sickle Cell Disease
- Careful adjustment of Epo non-viral gene therapy for β-thalassemic anaemia treatment
- Oxidative Stress and β-Thalassemic Erythroid Cells behind the Molecular Defect
- Exhaustive Running Exercise Induce Tyrosine Phosphorylation of Band 3 in Rat Erythrocytes
- Therapy with oral clotrimazole induces inhibition of the Gardos channel and reduction of erythrocyte dehydration in patients with sickle cell disease.
- Deficiency of Src family kinases Fgr and Hck results in activation of erythrocyte K/Cl cotransport.
- Blood transfusion in sickle cell disease.
- Hematologic and Clinical Responses of Thalassemia Intermedia Patients to Hydroxyurea During 6 Years of Therapy in Iran
- The Role of Recombinant Human Erythropoietin in the Treatment of Thalassemia
- Peroxiredoxin-2 expression is increased in β-thalassemic mouse red cells but is displaced from the membrane as a marker of oxidative stress
- Red blood cell indices, cation content, and membrane cation transports.
- Formation of dense erythrocytes in SAD mice exposed to chronic hypoxia: evaluation of different therapeutic regimens and of a combination of oral clotrimazole and magnesium therapies.
- A combined approach for β-thalassemia based on gene therapy-mediated adult hemoglobin (HbA) production and fetal hemoglobin (HbF) induction
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