Early induction of apoptosis in hematopoietic cell lines after exposure to flavopiridol.
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Summary
The results suggest that antiproliferative activity of flavopiridol (manifest by cell cycle arrest) may be separated in different cell types from a capacity to induce apoptosis and therefore clinical trials in hematopoietic neoplasms should be of high priority.
- Type
- article
- Published
- 1998-01-15
- Cited by
- 237
- References
- 46
- Access
- Open access
- OpenAlex
- https://openalex.org/W1527674890
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7462323
Keywords
Apoptosis, Cell cycle, Cyclin-dependent kinase 1, Cell cycle checkpoint, Biology
References
- Flavopiridol (L86 8275; NSC 649890), a new kinase inhibitor for tumor therapy.
- A human temperature-sensitive p53 mutant p53Val-138: modulation of the cell cycle, viability and expression of p53-responsive genes.
- Cancer cell lines
- A phase I trial of the cyclin-dependent kinase inhibitor flavopiridol in patients with refractory neoplasms
- Chemical inhibitors of cyclin-dependent kinases
- Unscheduled activation of cyclin B1/Cdc2 kinase in human promyelocytic leukemia cell line HL60 cells undergoing apoptosis induced by DNA damage.
- Effects of DNA methylation on topoisomerase I and II cleavage activities.
- Cell death: the significance of apoptosis.
- The role of proteases during apoptosis
- Alteration of the phosphorylation state of p34cdc2 kinase by the flavone L86-8275 in breast carcinoma cells. Correlation with decreased H1 kinase activity.
- Sublytic complement attack induces cell cycle in oligodendrocytes.
- 6-Mercaptopurine decreases the Bcl-2/Bax ratio and induces apoptosis in activated splenic B lymphocytes.
- Programmed cell death and the control of cell survival.
- Identification of deoxyribonuclease II as an endonuclease involved in apoptosis.
- Inhibition of DNA topoisomerases I and II and induction of apoptosis by erbstatin and tyrphostin derivatives.
- Suppression of Apoptosis by Dominant Negative Mutants of Cyclin-dependent Protein Kinases (*)
- Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.
- BCL‐2 family proteins: Regulators of cell death involved in the pathogenesis of cancer and resistance to therapy
- Potent inhibition of CDC2 kinase activity by the flavonoid L86-8275.
- Role of Ced-3/ICE-family proteases in staurosporine-induced programmed cell death
Cited by
- Purine analogs as CDK enzyme inhibitory agents: a survey and QSAR analysis.
- New drug development in non-hodgkin lymphomas
- The Raf signal transduction cascade as a target for chemotherapeutic intervention in growth factor-responsive tumors.
- A Phase II Trial of Flavopiridol (NSC #649890) in Patients with Previously Untreated Metastatic Androgen-Independent Prostate Cancer
- Metabolic reprogramming is associated with flavopiridol resistance in prostate cancer DU145 cells
- Treatment of relapsed or refractory chronic lymphocytic leukemia.
- Signal transduction mediated by cyclin D1: from mitogens to cell proliferation: a molecular target with therapeutic potential.
- Inhibitors of cyclin-dependent kinase modulators for cancer therapy.
- Role of Cell Cycle Control and Cyclin-Dependent Kinases in Breast Cancer
- Analysing the Effect of Mutation on Protein Function and Discovering Potential Inhibitors of CDK4: Molecular Modelling and Dynamics Studies
- Antitumour potential of BPT: a dual inhibitor of cdk4 and tubulin polymerization
- A p21(Waf1/Cip1)carboxyl-terminal peptide exhibited cyclin-dependent kinase-inhibitory activity and cytotoxicity when introduced into human cells.
- In-Silico Approaches to Multi-target Drug Discovery
- Flavopiridol: the First Cyclin-Dependent Kinase Inhibitor in Human Clinical Trials
- The expression of retinoblastoma and Sp1 is increased by low concentrations of cyclin-dependent kinase inhibitors.
- Characterization of molecular and cellular functions of the cyclin‐dependent kinase CDK9 using a novel specific inhibitor
- Successful Treatment of Animal Models of Rheumatoid Arthritis with Small-Molecule Cyclin-Dependent Kinase Inhibitors1
- Flavopiridol (alvocidib) in chronic lymphocytic leukemia
- Drug Resistance in Leukemia and Lymphoma III
- Flavopiridol binds to duplex DNA.
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