The competence progression model in CHO-K1 cells: the relationship between protein kinase C and immediate early gene expression in the insulin mitogenic signal.
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Summary
Pretreatment ofCHO-K1 cells with TPA or insulin decreases the required lag time for DNA synthesis by 3 h in a protein-synthesis-independent manner, demonstrating that the insulin signal is independent of PKC and insulin acts as a weak competence and a strong progression factor, while TPA behaves as a strong competence factor.
- Type
- article
- Published
- 1993-06-01
- Cited by
- 9
- References
- 37
- OpenAlex
- https://openalex.org/W1515741195
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:29005172
Keywords
Insulin, DNA synthesis, Insulin receptor, Hormone, Internal medicine
References
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- The platelet-derived growth factor-inducible KC gene encodes a secretory protein related to platelet alpha-granule proteins.
- Serum-inducible genes.
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- Platelet-derived growth factor-inducible genes respond differentially to at least two distinct intracellular second messengers.
- Distinct mechanisms of regulation of protein kinase C epsilon by hormones and phorbol diesters.
- Assembly of insulin/insulin-like growth factor-1 hybrid receptors in vitro.
- Insulin's regulation of c-fos gene transcription in hepatoma cells.
- Evidence for hybrid rodent and human insulin receptors in transfected cells.
- Identification of a set of genes expressed during the G0/G1 transition of cultured mouse cells.
- Insulin-like growth factor I receptor beta-subunit heterogeneity. Evidence for hybrid tetramers composed of insulin-like growth factor I and insulin receptor heterodimers.
- Insulin as a growth factor in rat hepatoma cells. Stimulation of proto-oncogene expression.
- Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.
- Complexity of the early genetic response to growth factors in mouse fibroblasts
- fra-1: a serum-inducible, cellular immediate-early gene that encodes a fos-related antigen
- Post-transcriptional control of the onset of DNA synthesis by an insulin-like growth factor
- Studies and perspectives of protein kinase C.
- Disappearance of Ca2+-sensitive, phospholipid-dependent protein kinase activity in phorbol ester-treated 3T3 cells.
- Mitogenic activity of phorbol esters and insulin-like growth factor 1 in chemically transformed mouse fibroblasts BP-A31: independent effects and differential sensitivity to inhibition by 3-isobutyl-1-methyl xanthine.
- Phosphoinositides in mitogenesis: neomycin inhibits thrombin-stimulated phosphoinositide turnover and initiation of cell proliferation.
Cited by
- Immediate early gene expression in dog thyrocytes in response to growth, proliferation, and differentiation stimuli
- Chinese hamster ovary cells produce sufficient recombinant insulin-like growth factor I to support growth in serum-free medium. Serum-free growth of IGF-I-producing CHO cells
- A phorbol ester-insensitive AP-1 motif mediates the stimulatory effect of insulin on rat malic enzyme gene transcription.
- Insulin‐Like Growth Factor‐I and Transferrin Mediate Growth and Survival of Chinese Hamster Ovary Cells
- The Adenosine Receptor and Serum Deprivation-Induced Neuronal Differentiation
- Life at the periphery: what makes CHO cells survival talents
- Insulin Could Selectively Accelerate Internalization of Slowly Cycling GPCRs
- Chinese hamster ovary cells produce sufficient recombinant insulin-like growth factor I to support growth in serum-free medium
- Control of Mammalian Cell Proliferation as an Important Strategy in Cell Culture Technology, Cancer Therapy and Tissue Engineering
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