Increased GABAA receptor binding in superficial layers of cingulate cortex in schizophrenics
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Summary
A preferential increase in bicuculline-sensitive 3H-muscimol binding on neuronal cell bodies of layers II and III, but not layers V and VI, of the schizophrenic cases is indicated, indicating a disturbance of inhibitory activity in these superficial layers of limbic cortex may contribute to the defective associative function seen in schizophrenia.
- Type
- article
- Published
- 1992-03-01
- Cited by
- 386
- References
- 58
- Access
- Open access
- OpenAlex
- https://openalex.org/W1514573559
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:17385861
Keywords
GABAA receptor, Neuropil, Muscimol, Bicuculline, Anterior cingulate cortex
References
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- Perinatal complications in adopted and non‐adopted schizophrenics and their controls: Preliminary results
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- γ-AMINOBUTYRIC-ACID DEFICIENCY IN BRAIN OF SCHIZOPHRENIC PATIENTS
Cited by
- Benzodiazepine receptor deficiency and tinnitus.
- Imaging as tool to investigate psychoses and antipsychotics.
- New Perspectives on the Clinical Neurobiology of Treatment Response in Schizophrenia
- Neuropeptide deficits in schizophrenia vs. Alzheimer's disease cerebral cortex.
- A reduction of nonpyramidal cells in sector CA2 of schizophrenics and manic depressives.
- The effects of benzodiazepines on event-related potential indices of automatic and controlled processing in schizophrenia: a preliminary report.
- Differences in the cellular distribution of D1 receptor mRNA in the hippocampus of bipolars and schizophrenics
- The human reelin gene: transcription factors (+), repressors (-) and the methylation switch (+/-) in schizophrenia.
- Histone hyperacetylation induces demethylation of reelin and 67-kDa glutamic acid decarboxylase promoters
- Possible contributions of myelin and oligodendrocyte dysfunction to schizophrenia.
- Recent cytoarchitechtonic changes in the prefrontal cortex of schizophrenics.
- Nicotinic receptors and functional regulation of GABA cell microcircuitry in bipolar disorder and schizophrenia.
- Synaptic dysfunction in schizophrenia.
- The regulation of subcortical dopamine systems by the prefrontal cortex: interactions of central dopamine systems and the pathogenesis of schizophrenia.
- Correlation between reduced in vivo benzodiazepine receptor binding and severity of psychotic symptoms in schizophrenia.
- Postmortem studies in schizophrenia
- Strategies for improving sensitivity of gene expression profiling: regulation of apoptosis in the limbic lobe of schizophrenics and bipolars.
- Additivities of Compounds that Increase the Numbers of High Affinity [3H]Muscimol Binding Sites by Different Amounts Define More than 9 GABAA Receptor Complexes in Rat Forebrain: Implications for Schizophrenia and Clozapine Research
- Strukturelle und funktionelle Hirnveränderungen bei schizophrenen Psychosen
- Alterations in neuromodulators of GABAergic transmission in the cerebellar cortex of patients with schizophrenia.
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