Estradiol Acts Directly on Bone Marrow Myeloid Progenitors to Differentially Regulate GM-CSF or Flt3 Ligand-Mediated Dendritic Cell Differentiation1
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Summary
It is demonstrated, using cytokine-driven culture models of DC differentiation, that 17-β-estradiol exerts opposing effects on differentiation mediated by GM-CSF and Flt3 ligand, the two cytokines that regulate DC differentiation in vivo.
- Type
- article
- Published
- 2008-01-15
- Cited by
- 132
- References
- 82
- Access
- Open access
- OpenAlex
- https://openalex.org/W1512751723
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21972534
Keywords
Cell biology, Myeloid, Biology, Dendritic cell, Cytokine
References
- Conservation of CD1 Intracellular Trafficking Patterns Between Mammalian Species1
- Activation of the Flt3 signal transduction cascade rescues and enhances type I interferon–producing and dendritic cell development
- Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells.
- Dendritic cells: specialized and regulated antigen processing machines.
- c-kit ligand and Flt3 ligand: stem/progenitor cell factors with overlapping yet distinct activities.
- Normative biology, immunology, and husbandry
- Identification of very early lymphoid precursors in bone marrow and their regulation by estrogen
- Sex differences in autoimmune disease
- Differences in dendritic cells stimulated in vivo by tumors engineered to secrete granulocyte-macrophage colony-stimulating factor or Flt3-ligand.
- A Gender Gap in Autoimmunity
- Interleukin-10 prevents dendritic cell accumulation and vaccination with granulocyte-macrophage colony-stimulating factor gene-modified tumor cells.
- The flt3 ligand promotes the survival of primitive hemopoietic progenitor cells with myeloid as well as B lymphoid potential. Suppression of apoptosis and counteraction by TNF-alpha and TGF-beta.
- Plasmacytoid Dendritic Cells of Different Origins Have Distinct Characteristics and Function: Studies of Lymphoid Progenitors versus Myeloid Progenitors
- Estrogen Selectively Promotes the Differentiation of Dendritic Cells with Characteristics of Langerhans Cells1
- The role of estrogen receptors and androgen receptors in sex steroid regulation of B lymphopoiesis.
- Estrogen Preferentially Promotes the Differentiation of CD11c+ CD11bintermediate Dendritic Cells from Bone Marrow Precursors1
- Effect of Granulocyte-Macrophage Colony-Stimulating Factor on the Generation of Epidermal Langerhans Cells
- Gender and risk of autoimmune diseases: possible role of estrogenic compounds.
- Cross‐talk between signal transducer and activator of transcription 3 and estrogen receptor signaling
- Sexual dimorphism in innate immune responses to infectious organisms
Cited by
- Terminal differentiation of dendritic cells.
- Etude de l'impact de l'exposition à des mélanges de pesticides à faibles doses : caractérisation des effets sur des lignées cellulaires humaines et sur le système hématopoïetique murin
- Obesity-driven inflammation and cancer risk: role of myeloid derived suppressor cells and alternately activated macrophages.
- Estrogen and Signaling in the Cells of Immune System
- Deficiency of type I IFN receptor in lupus-prone NZM 2328 mice decreases dendritic cell numbers and activation and protects from disease
- Usp18 promotes conventional CD11b+ dendritic cell development
- X-Chromosome Complement and Estrogen Receptor Signaling Independently Contribute to the Enhanced TLR7-Mediated IFN-α Production of Plasmacytoid Dendritic Cells from Women
- Estrogen receptor-dependent modulation of dendritic cell biology of mice and women
- Human haematopoietic stem/progenitor cells express several functional sex hormone receptors
- Epigenetic Regulation of Non-Lymphoid Cells by Bisphenol A, a Model Endocrine Disrupter: Potential Implications for Immunoregulation
- Phthalate esters modulate the differentiation and maturation of mouse peripheral blood mononuclear cell‐derived dendritic cells
- Coxsackievirus B3-induced myocarditis: infection of females during the estrus phase of the ovarian cycle leads to activation of T regulatory cells.
- Estrogen increases haematopoietic stem cell self-renewal in females and during pregnancy
- Chronic estradiol treatment reduces platelet responses and protects mice from thromboembolism through the hematopoietic estrogen receptor α.
- Estrogen Receptor Alpha Binding to ERE is Required for Full Tlr7- and Tlr9-Induced Inflammation
- Estrogen receptor-β ligand treatment modulates dendritic cells in the target organ during autoimmune demyelinating disease
- Estrogen receptor alpha modulates toll-like receptor signaling in murine lupus
- The identification and enumeration of dendritic cell populations from individual mouse spleen and Peyer's patches using flow cytometric analysis
- Estrogen receptor α and β in the normal immune system and in lymphoid malignancies.
- 17β-Estradiol and Interferon Tau Interact in the Regulation of the Immune Response in a Model of Experimental Autoimmune Orchitis
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