Distinct molecular profiles in Lynch syndrome‐associated and sporadic ovarian carcinomas
Explore this paper's citation graph
Summary
The significant molecular differences observed between LS‐associated and sporadic ovarian carcinomas help explain the different behavior of these tumors and emphasize the need for tailored clinical management.
- Type
- article
- Published
- 2013-12-01
- Cited by
- 38
- References
- 51
- Access
- Open access
- OpenAlex
- https://openalex.org/W1510100467
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23756301
Keywords
Serous fluid, KRAS, Clear cell, Ovarian cancer, Ovarian carcinoma
References
- Epigenetic signatures of familial cancer are characteristic of tumor type and family category.
- Distinct subtypes of serous ovarian carcinoma identified by p53 determination.
- Gene expression in ovarian cancer reflects both morphology and biological behavior, distinguishing clear cell from other poor-prognosis ovarian carcinomas.
- Cancer Statistics, 2007
- LINE-1 hypomethylation in familial and sporadic cancer
- Patterns of PIK3CA alterations in familial colorectal and endometrial carcinoma
- Clinicopathologic and biological analysis of PIK3CA mutation in ovarian clear cell carcinoma.
- Ovarian cancer linked to Lynch syndrome typically presents as early-onset, non-serous epithelial tumors.
- KRAS and BRAF mutations in ovarian tumors: a comprehensive study of invasive carcinomas, borderline tumors and extraovarian implants.
- Better survival rates in patients with MLH1-associated hereditary colorectal cancer.
- Comprehensive characterization of HNPCC-related colorectal cancers reveals striking molecular features in families with no germline mismatch repair gene mutations
- Pathogenesis of Ovarian Cancer: Lessons From Morphology and Molecular Biology and Their Clinical Implications
- A Review of the Clinical Relevance of Mismatch-Repair Deficiency in Ovarian Cancer
- Translational Application of Epigenetic Alterations: Ovarian Cancer as a Model
- Improved Classification of Epithelial Ovarian Cancer: Results of 3 Danish Cohorts
- PIK3CA overexpression is a possible prognostic factor for favorable survival in ovarian clear cell carcinoma.
- Reducing the risk of gynecologic cancer in the Lynch syndrome.
- Molecular genetics for the clinician
- Low-grade serous carcinomas of the ovary contain very few point mutations
- Immunohistochemical staining patterns of p53 can serve as a surrogate marker for TP53 mutations in ovarian carcinoma: an immunohistochemical and nucleotide sequencing analysis
Cited by
- DNA methylation changes in epithelial ovarian cancer histotypes
- Hereditary Ovarian Cancer: Not Only BRCA 1 and 2 Genes
- Molecular pathogenesis of ovarian clear cell carcinoma.
- Features of ovarian cancer in Lynch syndrome (Review).
- Distinct gene expression profiles in ovarian cancer linked to Lynch syndrome
- Clinicopathologic Analysis With Immunohistochemistry for DNA Mismatch Repair Protein Expression in Synchronous Primary Endometrial and Ovarian Cancers
- Epigenetic analysis of sporadic and Lynch-associated ovarian cancers reveals histology-specific patterns of DNA methylation
- Management of ovarian and endometrial cancers in women belonging to HNPCC carrier families: review of the literature and results of cancer risk assessment in Polish HNPCC families
- Epigenetic mechanisms in the pathogenesis of Lynch syndrome
- Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance: first report from the prospective Lynch syndrome database
- Oxidative stress in the pathogenesis and prognosis of ovarian cancer
- Ovarian cancer in Lynch syndrome; a systematic review.
- Update on Lynch syndrome genomics
- Intrinsic subtypes and prognostic implications in epithelial ovarian cancer
- The Role of Chromosomal Instability and Epigenetics in Colorectal Cancers Lacking β-Catenin/TCF Regulated Transcription
- Long‐term survival of patients with mismatch repair protein‐deficient, high‐stage ovarian clear cell carcinoma
- Genomic consequences of aberrant DNA repair mechanisms stratify ovarian cancer histotypes
- Sequencing of Lynch syndrome tumors reveals the importance of epigenetic alterations
- Molecular changes preceding endometrial and ovarian cancer: a study of consecutive endometrial specimens from Lynch syndrome surveillance
- Converging endometrial and ovarian tumorigenesis in Lynch syndrome: Shared origin of synchronous carcinomas.
Related papers
- Clear cell adenocarcinoma of the ovary: a clinical analysis and comparison with serous carcinoma.
- Mixed Clear Cell/Endometrioid and Clear Cell/Serous Carcinoma of the Uterus are Clinicopathologically Similar to Pure Clear Cell Carcinoma: An NRG Oncology/Gynecologic Oncology Group (GOG-210) Study of 311 Women
- A comparison of clinico-pathologic characteristics of patients with serous and clear cell carcinoma of the uterus
- Morphologic changes in ovarian carcinoma after neoadjuvant chemotherapy: report of a case showing extensive clear cell changes mimicking clear cell carcinoma.
- Minor Serous and Clear Cell Components Adversely Affect Prognosis in ‘‘Mixed-Type’’ Endometrial Carcinomas: A Clinicopathologic Study of 36 Stage-I Cases
- HNF-1β in Ovarian Carcinomas With Serous and Clear Cell Change
- Clear cell carcinoma of the endometrium is characterized by a distinctive profile of p53, Ki-67, estrogen, and progesterone receptor expression.
- Type-Specific Cell Line Models for Type-Specific Ovarian Cancer Research