The Role of K+ Currents in Frequency-Dependent Spike Broadening in Aplysia R20 Neurons: A Dynamic-Clamp Analysis
Explore this paper's citation graph
Summary
The dynamic-clamps technique, which employs computer simulation to inject biologically realistic currents into a cell under current-clamp conditions, was used either to block IAdepol or IK-V or to modify their inactivation properties to propose a hypothesis for the mechanism of spike broadening in the R20 cells.
- Type
- article
- Published
- 1996-07-01
- Cited by
- 114
- References
- 38
- Access
- Open access
- OpenAlex
- https://openalex.org/W1504378765
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11057754
Keywords
Repolarization, Biophysics, Electrophysiology, Aplysia, Patch clamp
References
- Contribution of individual ionic currents to activity of a model stomatogastric ganglion neuron.
- Cloning and expression of an Aplysia K+ channel and comparison with native Aplysia K+ currents
- SCP-containing R20 neurons modulate respiratory pumping in Aplysia
- Three types of early transient potassium currents in Aplysia neurons
- A model of the electrophysiological properties of thalamocortical relay neurons.
- An active membrane model of the cerebellar Purkinje cell. I. Simulation of current clamps in slice.
- Synaptic plasticity in the molluscan peripheral nervous system: physiology and role for peptides
- Dynamic clamp: computer-generated conductances in real neurons.
- The dynamic clamp: artificial conductances in biological neurons.
- A Shab potassium channel contributes to action potential broadening in peptidergic neurons.
- Action potential broadening and frequency-dependent facilitation of calcium signals in pituitary nerve terminals.
- A quantitative description of membrane current and its application to conduction and excitation in nerve
- Inactivation of voltage-gated delayed potassium current in molluscan neurons. A kinetic model.
- Three potassium channels in rat posterior pituitary nerve terminals.
- A‐current modifies the spike of C‐type neurones in the rabbit nodose ganglion.
- Inactivation properties of voltage-gated K+ channels altered by presence of β-subunit
- Overexpression of an Aplysia shaker K+ channel gene modifies the electrical properties and synaptic efficacy of identified Aplysia neurons.
- Inactivation of delayed outward current in molluscan neurone somata.
- State-dependent inactivation of the Kv3 potassium channel.
- Modulation of K+ current by frequency and external [K+]: a tale of two inactivation mechanisms.
Cited by
- Modulation of excitability as a learning and memory mechanism: a molecular genetic perspective.
- Background potassium concentrations and epileptiform discharges. II. Involvement of calcium channels.
- IA in Kenyon cells of the mushroom body of honeybees resembles shaker currents: kinetics, modulation by K+, and simulation.
- Interaction between synaptic conductances and action potential initiation in cortical neurons: computational models and analysis of intracellular recordings
- Control of Spiking Activity by Persistent Sodium and Hyperpolarization-activated Currents
- K+ Channels: Function‐Structural Overview
- Diminished A‐type potassium current and altered firing properties in presympathetic PVN neurones in renovascular hypertensive rats
- Dynamic Regulation of Calcium Influx by G-Proteins, Action Potential Waveform, and Neuronal Firing Frequency
- Ionic Mechanisms of Endogenous Bursting in CA3 Hippocampal Pyramidal Neurons: A Model Study
- Real-Time Linux Dynamic Clamp: A Fast and Flexible Way to Construct Virtual Ion Channels in Living Cells
- Analytical solutions of the Frankenhaeuser-Huxley equations I: minimal model for backpropagation of action potentials in sparsely excitable dendrites.
- Interneuron Diversity series: Fast in, fast out--temporal and spatial signal processing in hippocampal interneurons.
- Mechanisms of sustained high firing rates in two classes of vestibular nucleus neurons: differential contributions of resurgent Na, Kv3, and BK currents.
- The Phantom Burster Model for Pancreatic β-Cells
- Potassium Channels and Signal Transduction Pathways in Neurons
- The Past, Present, and Future of Real-Time Control in Cellular Electrophysiology
- Multiple forms of facilitation produced by aversive tentacular stimuli in cerebral ganglion sensory neurons of Aplysia.
- Modulation of the bursting properties of single mouse pancreatic beta-cells by artificial conductances.
- The role of BK‐type Ca2+‐dependent K+ channels in spike broadening during repetitive firing in rat hippocampal pyramidal cells
- Dynamic clamp analyses of cardiac, endocrine, and neural function.
Related papers
- An oxygen dependent current in Aplysia neurons: an approach to the question of cellular hypoxic adaptation.
- Regenerative repolarization of the frog ventricular action potential: a time and voltage‐dependent phenomenon.
- Whole-cell and Perforated Patch-clamp Recordings from Acutely-isolated Murine Sino-atrial Node Cells.
- Patch-clamp recording of voltage-sensitive Ca2+ channels.
- Excitement Over Automated Patch Clamp: Action Potentials from Cardiac Myocytes
- Role of an inwardly rectifying potassium current in rabbit ventricular action potential.
- Advances in patch clamp technique: towards higher quality and quantity.
- Dynamic clamp as a tool to study the functional effects of individual membrane currents.