Thymic epithelial cells in age‐dependent involution
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Summary
Structural and phenotypic modifications of TEC are locally controlled by complex sets of different factors and seem to represent a morphological adaptation of the gland to the process of aging.
- Type
- review
- Published
- 2003-12-15
- Cited by
- 39
- References
- 103
- Access
- Open access
- OpenAlex
- https://openalex.org/W1503157159
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21237755
Keywords
TEC, Involution (esoterism), Thymic involution, Biology, Phenotype
References
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- The effect of castration, oestrogens, testosterone and the oestrous cycle on the cortical epithelium of the thymus in male and female rats.
- The human thymic microenvironment. Phenotypic characterization of Hassall's bodies with the use of monoclonal antibodies.
- Medullary thymic epithelium expresses a ligand for CTLA4 in situ and in vitro.
- Age involution in the normal human adult thymus.
- Molecular and cellular events of T cell development.
- Thymic nurse cells are sites of thymocyte apoptosis.
- Age-associated thymic atrophy in the mouse is due to a deficiency affecting rearrangement of the TCR during intrathymic T cell development.
- Reduced expression of Ia antigens by thymic epithelial cells of aged mice.
- Failure of rearranged TCR transgenes to prevent age-associated thymic involution.
- Human thymic epithelial cells produce interleukin 1.
- IL-7 and Not Stem Cell Factor Reverses Both the Increase in Apoptosis and the Decline in Thymopoiesis Seen in Aged Mice1
- Immuno‐electron microscopy of the thymic epithelial microenvironment
Cited by
- Are zinc-bound metallothionein isoforms (I+II and III) involved in impaired thymulin production and thymic involution during ageing?
- Thymic involution: implications for self-tolerance.
- Age-Associated Remodeling of Thymopoiesis: Role for Gonadal Hormones and Catecholamines
- The role of sex steroids and gonadectomy in the control of thymic involution.
- Immunotherapy for Prostate Cancer – Recent Developments and Future Challenges
- Immunosenescence: deficits in adaptive immunity in the elderly.
- Neurotrophins - More than Neurotrophic
- Characteristics of age-related changes in rat thymus: morphometric analysis and epithelial cell network in various thymic compartments
- Thymus as a target tissue of glucocorticoid action: What are the consequences of glucocorticoids thymectomy?
- Histochemical and molecular overview of the thymus as site for T-cells development.
- Protection of immunocompromised mice from fungal infection with a thymus growth-stimulatory component from Selaginella involvens, a fern
- Thymic Involution: Where Endocrinology Meets Immunology
- Immunosenescence: emerging challenges for an ageing population
- Phenotype of Genetically Regulated Thymic Involution in Young BXD RI Strains of Mice
- Immunosenescence: immune deficits in the elderly and therapeutic strategies to enhance immune competence
- The contribution of thymic stromal abnormalities to autoimmune disease.
- Insights into thymic aging and regeneration
- Immunosenescence and Anti-Immunosenescence Therapies: The Case of Probiotics
- Thymus and aging: morphological, radiological, and functional overview
- Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation
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