Substrate recognition determinants of the mitogen-activated 70K S6 kinase from rat liver.
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Summary
A synthetic peptide containing a putative 70K S6 kinase autoinhibitory domain did not serve as a substrate for the enzyme but did inhibit its activity, although much less effectively than a synthetic peptides containing all the recognition determinants.
- Type
- article
- Published
- 1992-02-15
- Cited by
- 163
- References
- 28
- Access
- Open access
- OpenAlex
- https://openalex.org/W1499220263
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22362186
Keywords
Substrate (aquarium), Kinase, Mitogen-activated protein kinase, Protein kinase A, Chemistry
References
- Structure, expression, and regulation of protein kinases involved in the phosphorylation of ribosomal protein S6.
- Magnetic resonance studies of the effect of the regulatory subunit on metal and substrate binding to the catalytic subunit of bovine heart protein kinase.
- Purification of a hepatic S6 kinase from cycloheximide-treated Rats.
- Phosphorylation of hepatic ribosomal protein S6 on 80 and 40 S ribosomes. Primary structure of S6 in the region of the major phosphorylation sites for cAMP-dependent protein kinases.
- Mitogen-activated 70K S6 kinase. Identification of in vitro 40 S ribosomal S6 phosphorylation sites.
- Protein kinases. Regulation by autoinhibitory domains.
- Regulation of initiation factors during translational repression caused by serum depletion. Covalent modification.
- The influence of basic residues on the substrate specificity of protein kinase C.
- Protein phosphorylation controls translation rates.
- Purification and characterization of a 40 S ribosomal protein S6 kinase from vanadate-stimulated Swiss 3T3 cells.
- Purification and characterization of ribosomal protein S6 kinase I from Xenopus eggs.
- Purification and characterization of a protein kinase from Xenopus eggs highly specific for ribosomal protein S6.
- Role of acidic residues as substrate determinants for casein kinase I.
- Identification of the 40 S ribosomal protein S6 phosphorylation sites induced by cycloheximide.
- Relative stoichiometry in ribosomal proteins in HeLa cell nucleoli.
- An activated S6 kinase in extracts from serum- and epidermal growth factor-stimulated Swiss 3T3 cells.
- Identification of multiple epidermal growth factor-stimulated protein serine/threonine kinases from Swiss 3T3 cells.
- The determination of enzyme inhibitor constants.
- Intracellular messengers and the control of protein synthesis.
- MAP2 kinase and 70K S6 kinase lie on distinct signalling pathways
Cited by
- Cholecystokinin Activation of 70-kDa S6 Kinase in Exocrine Pancreas
- Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway.
- Androgen-sensitive microsomal signaling networks coupled to the proliferation and differentiation of human prostate cancer cells.
- Regulation of p70s6k/p85s6k and its role in the cell cycle.
- Physiological roles of ribosomal protein S6: one of its kind.
- Ribosomal protein S6 kinase from TOP mRNAs to cell size.
- Regulation of Blood–Testis Barrier (BTB) Dynamics during Spermatogenesis via the “Yin” and “Yang” Effects of Mammalian Target of Rapamycin Complex 1 (mTORC1) and mTORC2
- Molecular and hormonal responses and adaptation to resistance and protein nutrition in young and older men
- p70 S6 Kinase and Tau in Alzheimer's Disease
- Protein Kinase Cα Is Implicated in Cholecystokinin-Induced Activation of 70-kd S6 Kinase in AR42J Cells
- Tyrosine Phosphorylation/Dephosphorylation and Downstream Signalling
- Modulation par le récepteur neurokinine-1du mécanisme d’action des immunosuppresseurs chez les cellules T
- Hormonal and Nutrient Signalling to Protein Kinase B and Mammalian Target of Rapamycin in Pancreatic Beta-Cells
- Identification and functional studies of two novel serine phosphorylation sites of insulin receptor substrate (IRS)-2: Ser 675 and Ser 907
- Role of S6 phosphorylation and S6 kinase in cell growth.
- Study of nuclear targets of phosphatidylinositol-3 kinase in lymphocytes
- Phosphorylated S6 Ribosomal Protein: A Novel Biomarker of Antibody‐Mediated Rejection in Heart Allografts
- S6 phosphorylation and the p70s6k/p85s6k.
- A dominant-negative mutant of mSOS1 inhibits insulin-induced Ras activation and reveals Ras-dependent and -independent insulin signaling pathways
- Mutations in the Drosophila gene encoding ribosomal protein S6 cause tissue overgrowth
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