Loss of the polyadenylate segment from mammalian messenger RNA. Selective cleavage of this sequence from polyribosomes.
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Summary
It is suggested that the 3′ non-coding region of mRNA in polysomes is particularly sensitive to endonucleolytic cleavage, and that loss of poly(A) via this cleavage may be a normal cellular process.
- Type
- article
- Published
- 1980-05-25
- Cited by
- 25
- References
- 20
- OpenAlex
- https://openalex.org/W1498064757
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9178782
Keywords
Polysome, Micrococcal nuclease, Messenger RNA, Population, RNA
References
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- Properties of sea urchin embryo messenger RNA containing and lacking poly(A).
- Eukaryotic messenger RNA.
Cited by
- A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation.
- The regulatory function of poly(A) and adjacent 3' sequences in translated RNA.
- mRNA poly(A) tail, a 3' enhancer of translational initiation
- Analysis in Cos-1 cells of processing and polyadenylation signals by using derivatives of the herpes simplex virus type 1 thymidine kinase gene
- Transcription and polyadenylation processes during early development of quail embryo.
- Preparation of a "functional library" of African green monkey DNA fragments which substitute for the processing/polyadenylation signal in the herpes simplex virus type 1 thymidine kinase gene
- Regulation of messenger RNA stability in mouse erythroleukemia cells.
- Molecular cloning of the acid-labile subunit of the rat insulin-like growth factor binding protein complex.
- Messenger RNA changes during differentiation of murine erythroleukemia cells.
- Functional characteristics of untranslated messenger ribonucleoprotein particles from mouse sarcoma ascites cells. Possible relation to the control of messenger RNA utilization.
- The Role of the poly(A) sequence in mammalian messenger RNA.
- Cytoplasmic processing events in the polyadenylate region of Physarum messenger RNA
- Minamata disease: what is a keystone of its molecular mechanism? A biochemical theory on the nature of methyl mercury neurotoxicity.
- The metabolism of SV40 RNA is associated with the cytoskeletal framework.
- Poly(A) length, cytoplasmic adenylation and synthesis of poly(A)+ RNA in early mouse embryos.
- Structure and function of rat liver polysome populations. I. Complexity, frequency distribution, and degree of uniqueness of free and membrane-bound polysomal polyadenylate-containing RNA populations
- Differential compartmentalization of messenger ribonucleic acid in murine testis.
- Novel electrophoretic approach to study of poly(A)+RNA pool heterogeneity in different areas of human postmortem brain.
- Modulation of messenger RNA metabolism in experimental methyl mercury neurotoxicity.
- Human Hemoglobin Genetics
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