An Abrupt Shift in the Day/Night Cycle Causes Desynchrony in the Mammalian Circadian Center
Explore this paper's citation graph
Summary
It is demonstrated that an abrupt shift in the light/dark (LD) cycle disrupts the synchronous oscillation of circadian components in the rat SCN and dissociation and slow resynchronization of endogenous oscillators within the SCN after an LD cycle shift suggests a mechanism for the physiological symptoms that constitute jet lag.
- Type
- article
- Published
- 2003-07-09
- Cited by
- 275
- References
- 56
- Access
- Open access
- OpenAlex
- https://openalex.org/W1497737563
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:15182838
Keywords
PER1, Circadian rhythm, Suprachiasmatic nucleus, PER2, Internal medicine
References
- Photic and circadian regulation of c-fos gene expression in the hamster suprachiasmatic nucleus.
- Synaptic communication of cellular oscillations in the rat suprachiasmatic neurons.
- Re-entrainment of circadian rhythms after phase-shifts of the Zeitgeber.
- Suprachiasmatic nucleus: the mind's clock
- Clock controls circadian period in isolated suprachiasmatic nucleus neurons
- Temporal chimeras produced by hypothalamic transplants
- Eukaryotic circadian systems: cycles in common
- Cryptic clues to clock function
- Circadian oscillation of a mammalian homologue of the Drosophila period gene
- Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms
- Phase shifting two coupled circadian pacemakers: implications for jet lag.
- Development of Vasoactive Intestinal Peptide mRNA Rhythm in the Rat Suprachiasmatic Nucleus
- Individual neurons dissociated from rat suprachiasmatic nucleus express independently phased circadian firing rhythms.
- mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop.
- Circadian surfaces and the diversity of possible roles of circadian organization in photoperiodic induction.
- Circadian rhythmic changes of neuronal activity in the suprachiasmatic nucleus of the rat hypothalamic slice.
- Neuronal synchronization without calcium-dependent synaptic transmission in the hypothalamus.
- Per1 and Per2 gene expression in the rat suprachiasmatic nucleus: circadian profile and the compartment-specific response to light.
- Two coupled oscillators: simulations of the circadian pacemaker in mammalian activity rhythms.
- Persistence of circadian rhythmicity in a mammalian hypothalamic "island" containing the suprachiasmatic nucleus.
Cited by
- Suprachiasmatic nucleus: cellular clocks and networks.
- The effects of switching light-dark regime on the behavior of Wistar rats.
- Intrinsic Regulation of Spatiotemporal Organization within the Suprachiasmatic Nucleus
- Commentary: miR-132/212 Modulates Seasonal Adaptation and Dendritic Morphology of the Central Circadian Clock
- Health consequences of circadian disruption in humans and animal models.
- Photoperiodic Properties of Circadian Rhythm in Rat.
- Dynamic neuronal network organization of the circadian clock and possible deterioration in disease.
- Photic and non-photic inputs to the suprachiasmatic nucleus of the rat: role of the serotonergic system
- Circadian timing in health and disease.
- The circadian clock in the brain: a structural and functional comparison between mammals and insects
- Synchronization of Biological Clock Neurons by Light and Peripheral Feedback Systems Promotes Circadian Rhythms and Health
- The circadian timing system: a recent addition in the physiological mechanisms underlying pathological and aging processes.
- Constructing the suprachiasmatic nucleus: a watchmaker's perspective on the central clockworks
- INVESTIGATIONS OF CIRCADIAN REGULATION AND IMMUNE-CIRCADIAN INTERACTION IN THE HORSE
- Phase-delay in the light-dark cycle impairs clock gene expression and levels of serotonin, norepinephrine, and their metabolites in the mouse hippocampus and amygdala.
- AUTONOMIC NERVOUS SYSTEM ACTIVITY DURING ACCLIMATIZATION AFTER RAPID AIR TRAVEL ACROSS TIME ZONES: A CASE STUDY
- Synchrony and desynchrony in circadian clocks: impacts on learning and memory
- La desincronización interna como promotora de enfermedad y problemas de conducta
- Spatiotemporal profiles of arginine vasopressin transcription in cultured suprachiasmatic nucleus
- Topological specificity and hierarchical network of the circadian calcium rhythm in the suprachiasmatic nucleus
Related papers
- Insight into molecular core clock mechanism of embryonic and early postnatal rat suprachiasmatic nucleus.
- Antibodies for Assessing Circadian Clock Proteins in the Rodent Suprachiasmatic Nucleus
- Restricted feeding regime affects clock gene expression profiles in the suprachiasmatic nucleus of rats exposed to constant light.
- Vasoactive intestinal polypeptide induces per1 and per2 gene expression in the rat suprachiasmatic nucleus late at night
- Development of the light sensitivity of the clock genes Period1 and Period2, and immediate‐early gene c‐fos within the rat suprachiasmatic nucleus
- Temporal profile of circadian clock gene expression in a transplanted suprachiasmatic nucleus and peripheral tissues
- Regulation of circadian gene expression in the kidney by light and food cues in rats.
- Effects of Vasoactive Intestinal Peptide Genotype on Circadian Gene Expression in the Suprachiasmatic Nucleus and Peripheral Organs