Identification of a novel integrin beta subunit expressed on cultured monocytes (macrophages). Evidence that one alpha subunit can associate with multiple beta subunits.
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Summary
It is shown that the vitronectin receptor is absent from the surface of monocytes freshly isolated from blood but is expressed on these cells after a period of in vitro culture, suggesting a role for the novel receptor complex during monocyte/macrophage differentiation.
- Type
- article
- Published
- 1990-01-15
- Cited by
- 77
- References
- 0
- Access
- Open access
- OpenAlex
- https://openalex.org/W1495650014
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20662203
Keywords
Molecular biology, G alpha subunit, Polyclonal antibodies, Interleukin 12 receptor, beta 1 subunit, Vitronectin
References
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Cited by
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- Antigen markers of macrophage differentiation in murine tissues.
- Individual cell analysis of the cytokine repertoire in human immunodeficiency virus-1-infected monocytes/macrophages by a combination of immunocytochemistry and in situ hybridization.
- Adhesion in Leukocyte Homing and Differentiation
- Characterization of the integrin alpha(v) gene promoter in mice.
- Vitronectin-driven human keratinocyte locomotion is mediated by the alpha v beta 5 integrin receptor.
- Osteopontin expression and distribution in human carcinomas.
- Platelets induce monocyte differentiation in serum‐free coculture
- Adhesion receptors of the immune system
- Macrophages of multiple sclerosis patients display deficient SHP-1 expression and enhanced inflammatory phenotype
- Identification of integrin receptors on cultured human bone cells
- Integrins alpha v beta 3 and alpha v beta 5 contribute to cell attachment to vitronectin but differentially distribute on the cell surface
- Identity between the novel integrin beta 7 subunit and an antigen found highly expressed on intraepithelial lymphocytes in the small intestine.
- Increased expression of laminin receptors during myeloid differentiation
- Nonimmune phagocytosis of liposomes by rat alveolar macrophages is enhanced by vitronectin and is vitronectin-receptor mediated.
- Antibody-defined cell surface molecules of the immune system.
- Transglutaminase 2 is expressed and active on the surface of human monocyte-derived dendritic cells and macrophages.
- Targeting leukocyte integrins in human diseases
- The role of the microenvironment and intercellular cross-talk in tumor angiogenesis.
- The Leukocyte Integrins*
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