Multiple Muscarinic Acetylcholine Receptor Subtypes Modulate Striatal Dopamine Release, as Studied with M1–M5 Muscarinic Receptor Knock-Out Mice
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Summary
Results provide unambiguous evidence that multiple mAChR subtypes are involved in the regulation of striatal dopamine release and should contribute to a better understanding of the important functional roles that the muscarinic cholinergic system plays in striatal function.
- Type
- article
- Published
- 2002-08-01
- Cited by
- 227
- References
- 46
- Access
- Open access
- OpenAlex
- https://openalex.org/W1494737704
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:18656341
Keywords
Oxotremorine, Muscarinic acetylcholine receptor, Muscarinic acetylcholine receptor M4, Dopamine, Dopaminergic
References
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- Distribution of m1-m4 muscarinic receptor proteins in the rat striatum: light and electron microscopic immunocytochemistry using subtype- specific antibodies
- Characterization of Central Inhibitory Muscarinic Autoreceptors by the Use of Muscarinic Acetylcholine Receptor Knock-Out Mice
- Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies
- Heterogeneity of presynaptic muscarinic receptors regulating neurotransmitter release in the rat brain.
- Muscarinic receptors--characterization, coupling and function.
- Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean
- Interacting Presynaptic k‐Opioid and GABAA Receptors Modulate Dopamine Release from Rat Striatal Synaptosomes
- Muscarinic receptors mediate direct inhibition of GABA release from rat striatal nerve terminals.
- Muscarinic Modulation of Striatal Dopamine, Glutamate, and GABA Release, as Measured with In Vivo Microdialysis
- Modulatory functions of neurotransmitters in the striatum: ACh/dopamine/NMDA interactions.
- Muscarinic receptors on dopamine terminals in the cat caudate nucleus: neuromodulation of [3H]dopamine release in vitro by endogenous acetylcholine.
- Neurotransmitters and neuromodulators in the basal ganglia.
- Effect of M1- and M2-muscarinic drugs on striatal dopamine release and metabolism: an in vivo microdialysis study comparing normal and 6-hydroxydopamine-lesioned rats.
- Synaptic integration mediated by striatal cholinergic interneurons in basal ganglia function.
- Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M3 subtype.
- Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice.
- Localization of m5 muscarinic receptor mRNA in rat brain examined by in situ hybridization histochemistry.
Cited by
- Novel muscarinic receptor mutant mouse models.
- Sedation and antinociception induced by a new pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine derivative (LASSBio-873) is modulated by activation of muscarinic receptors.
- The M₁/M₄ preferring agonist xanomeline reverses amphetamine-, MK801- and scopolamine-induced abnormalities of latent inhibition: putative efficacy against positive, negative and cognitive symptoms in schizophrenia.
- Section I. The cholinergic system.
- Muscarinic receptors in schizophrenia: is there a role for synaptic plasticity?
- Cholinergic interneurons and synaptic reorganization within the nucleus accumbens shell and core: Potential neural substrates underlying drug addiction
- Alteration in behavioral sensitivity to amphetamine after treatment with oxotremorine. Effect of dose and test environment.
- Muscarinic mechanisms in psychotic disorders.
- Chronic treatment with simvastatin affects cannabinoid receptor type 1 and muscarinic receptors type 2/4 in different brain regions among sham and 6-hydroxydopamine lesioned rats
- Neurotrophic factors modulation by adenosine receptors and dopamine release in the rat striatum
- Allosteric interactions at the M3 muscarinic acetylcholine receptor
- Muscarinic agonists and antagonists in schizophrenia: recent therapeutic advances and future directions.
- Association Study of CHRM2 Polymorphisms with Substance-Use Pathology and Personality Traits
- Impact of species variability and ‘probe‐dependence’ on the detection and in vivo validation of allosteric modulation at the M4 muscarinic acetylcholine receptor
- Acute β-Amyloid Administration Disrupts the Cholinergic Control of Dopamine Release in the Nucleus Accumbens
- Muscarinic receptor subtype pharmacology and physiology.
- Functional neurochemistry of the basal ganglia.
- M4 muscarinic receptors regulate the dynamics of cholinergic and dopaminergic neurotransmission: relevance to the pathophysiology and treatment of related central nervous system pathologies
- Release‐enhancing pre‐synaptic muscarinic and nicotinic receptors co‐exist and interact on dopaminergic nerve endings of rat nucleus accumbens
- Presynaptic nicotinic receptors: a dynamic and diverse cholinergic filter of striatal dopamine neurotransmission
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