Inflammation Induces Myeloid-Derived Suppressor Cells that Facilitate Tumor Progression1

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Summary

It is suggested that inflammation promotes malignancy via proinflammatory cytokines, such as IL-1β, which enhance immune suppression through the induction of MSC, thereby counteracting immune surveillance and allowing the outgrowth and proliferation of malignant cells.

Type
article
Published
2006-01-01
Cited by
579
References
41
Access
Open access

Keywords

Proinflammatory cytokine, Inflammation, Tumor microenvironment, Immune system, Myeloid-derived Suppressor Cell

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