Inflammation Induces Myeloid-Derived Suppressor Cells that Facilitate Tumor Progression1
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Summary
It is suggested that inflammation promotes malignancy via proinflammatory cytokines, such as IL-1β, which enhance immune suppression through the induction of MSC, thereby counteracting immune surveillance and allowing the outgrowth and proliferation of malignant cells.
- Type
- article
- Published
- 2006-01-01
- Cited by
- 579
- References
- 41
- Access
- Open access
- OpenAlex
- https://openalex.org/W1494453913
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24000962
Keywords
Proinflammatory cytokine, Inflammation, Tumor microenvironment, Immune system, Myeloid-derived Suppressor Cell
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Cited by
- The role of LL-37 in prostate cancer and its potential as a therapeutic target
- Tumor Heterogeneity: Mechanisms and Bases for a Reliable Application of Molecular Marker Design
- PXR and NF-κB correlate with the inducing effects of IL-1β and TNF-α on ABCG2 expression in breast cancer cell lines.
- The role of inflammation in head and neck cancer.
- Increase in CD14+HLA-DR−/low myeloid-derived suppressor cells in hepatocellular carcinoma patients and its impact on prognosis
- Immune Modulation by Chemotherapy or Immunotherapy to Enhance Cancer Vaccines
- Exosomes from myeloid derived suppressor cells carry biologically active proteins
- microRNA-155 Deficiency Enhances the Recruitment and Functions of Myeloid-Derived Suppressor Cells in Tumor Microenvironment and Promotes Solid Tumor Growth
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- Evaluación de la actividad antitumoral de una fracción de Caesalpinia Spinosa en un modelo de cáncer mamario murino
- Initiation and regulation of effector T cell responses in the prostate
- Interleukin-10 in the Control of Tumor Immunity and Autoimmunity.
- Regulation by IL-10 of innate immune responses to MUC1 as a self-antigen in MUC1 transgenic mice
- The role of inflammation in the pathogenesis of non-small cell lung cancer.
- MANIPULATION OF REGULATORY MYELOID CELL DIFFERENTIATION AND FUNCTION AND ITS THERAPEUTIC IMPLICATIONS
- Bioluminescent mouse models of prostate cancer progression and therapy
- Protumor effects of proinflammatory mediators in breast cancer
- Myeloid-Derived Suppressor Cells: Critical Cells Driving Immune Suppression in the Tumor Microenvironment
- The Role of Myeloid-Derived Suppressor Cells in the Immunotherapy of HER2/neu-Positive Breast Carcinomas
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