IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways.

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Summary

Results support an IL-17R-mediated signaling pathway involving JAK and NF-kappaB in the transcriptional stimulation of hBD-2 gene expression in airway epithelium.

Type
article
Published
2004-09-01
Cited by
242
References
0
Access
Open access

Keywords

Respiratory epithelium, Autocrine signalling, Signal transduction, Reporter gene, Paracrine signalling

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