Effect of malonaldehyde and acetaldehyde on cultured mammalian cells. Production of micronuclei and chromosomal aberrations.
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Summary
Dose-dependent increases in aneuploidy were seen at 10(-4) M and higher concentrations of both aldehydes, with incidences twice as high for MA as for AA.
- Type
- article
- Published
- 1982-05-01
- Cited by
- 85
- References
- 22
- OpenAlex
- https://openalex.org/W1490632139
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:26532996
Keywords
Micronucleus test, Acetaldehyde, Molecular biology, Aneuploidy, Micronucleus
References
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- A SURVEY OF THE MALONALDEHYDE CONTENT OF RETAIL MEATS AND FISH
- Identification of malondialdehyde as the TBA‐reactant formed by bleomycin‐iron free radical damage to DNA
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- Effect of malonaldehyde and acetaldehyde on cultured mammalian cells: Growth, morphology, and synthesis of macromolecules.
- Autoxidation of polyunsaturated fatty acids. Part I. Effect of ozone on the autoxidation of neat methyl linoleate and methyl linolenate.
- Mutagenicity of malonaldehyde, a decomposition product of peroxidized polyunsaturated fatty acids.
- Malonaldehyde content of food.
- Increase of peroxidation in carcinogenesis.
- Molecular Mechanisms of Mutations
Cited by
- Oxygen radicals and human disease.
- Alkoholinduzierte Erkrankungen im Kopf-Hals-Bereich
- Phenolic-dependent anti-lipid peroxidative, antimodulatory and antioxidant activity of virgin coconut oil in vitro.
- Prostaglandins in Cancer Research
- Estudo Morfométrico do Plexo Mientérico do Duodeno de Ratos Submetidos ao Alcoolismo
- Chromosome damage induced by vinyl acetate through in vitro formation of acetaldehyde in human lymphocytes and Chinese hamster ovary cells.
- Putative mutagens and carcinogens in foods. IV. Malonaldehyde (malondialdehyde).
- The etiology of alcohol-induced breast cancer.
- Removal of acetaldehyde from saliva by a slow‐release buccal tablet of L‐cysteine
- Increased frequency of micronuclei in peripheral blood lymphocytes of subjects infected with Helicobacter pylori.
- Induction of genotoxicity by salted deep-fried fish and mutton.
- A mutagenicity assessment of acetaldehyde.
- In vitro micronucleus assay for cigarette smoke using a whole smoke exposure system: a comparison of smoking regimens.
- Vitamin E protects against methyl ethyl ketone peroxide-induced peroxidative damage to rat brain DNA.
- Malondialdehyde, a major endogenous lipid peroxidation product, sensitizes human cells to UV- and BPDE-induced killing and mutagenesis through inhibition of nucleotide excision repair.
- Genotoxicity of an organochlorine pesticide dichlorophene by micronucleus and chromosomal aberration assays using bone marrow cells of Rattus norvegicus
- Mutagenicity tests of cashewnut shell liquid, rice-bran oil and other vegetable oils using the Salmonella typhimurium/microsome system.
- DNA‐damaging activity of biotic and xenobiotic aldehydes in chinese hamster ovary cells
- Evaluation of twelve potential aneuploidogenic chemicals by the in vitro human lymphocyte micronucleus assay.
- Modification of human serum low density lipoprotein by oxidation--characterization and pathophysiological implications.
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