The Ca2+ release-activated Ca2+ current (ICRAC) mediates store-operated Ca2+ entry in rat microglia
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Summary
It is demonstrated that Orai1/CRAC channels are responsible for SOCE in primary microglia, rather than any known TRP channel, as supported by patch-clamp electrophysiological analysis.
- Type
- article
- Published
- 2009-03-15
- Cited by
- 101
- References
- 79
- Access
- Open access
- OpenAlex
- https://openalex.org/W1489975469
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25661298
Keywords
TRPC3, ORAI1, Transient receptor potential channel, TRPC, Chemistry
References
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- Modulation of the ERG K+ Current by the Tyrosine Phosphatase, SHP-1*
- Regulation of an ERG K+ Current by Src Tyrosine Kinase*
- Properties of heterologously expressed hTRP3 channels in bovine pulmonary artery endothelial cells
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Cited by
- Transient Receptor Potential Canonical 7 (TRPC7): A Diacylglycerol-Activated Non-Selective Cation Channel
- Pharmacological Profiling of Store‐Operated Ca2+ Entry in Retinal Arteriolar Smooth Muscle
- Store-operated Ca(2+) entry.
- TRPC4- and TRPC4-containing channels.
- Calcium signaling in glioma cells--the role of nucleotide receptors.
- The neglected CRAC proteins: Orai2, Orai3, and STIM2.
- Perfluorooctane sulfonate mediates microglial activation and secretion of TNF-α through Ca²⁺-dependent PKC-NF-кB signaling.
- Calcium ion influx in microglial cells: Physiological and therapeutic significance
- Store-Operated Calcium Channels in the Function of Intracardiac Neurons
- Expression and contributions of the Kir2.1 inward-rectifier K+ channel to proliferation, migration and chemotaxis of microglia in unstimulated and anti-inflammatory states
- Brain transient receptor potential channels and stroke
- The involvement of activated microglia in the cardiovascular complications of diabetes and heart failure
- Dominance of E. coli phagocytosis over LPS in the inflammatory response of microglia.
- TRPM2 Cation Channels, Oxidative Stress and Neurological Diseases: Where Are We Now?
- Selective Activation of KCa3.1 and CRAC Channels by P2Y2 Receptors Promotes Ca2+ Signaling, Store Refilling and Migration of Rat Microglial Cells
- Diethylstilbestrol and Other Nonsteroidal Estrogens: Novel Class of Store-Operated Calcium Channel Modulators
- TRPM2 Contributes to Inflammatory and Neuropathic Pain through the Aggravation of Pronociceptive Inflammatory Responses in Mice
- Biphasic effects of nitric oxide on calcium influx in human platelets.
- Nörolojik Hücrelerde TRPM2 Katyon Kanallarının Moleküler Mekanizmalardaki Rolleri
- PKA Reduces the Rat and Human KCa3.1 Current, CaM Binding, and Ca2+ Signaling, Which Requires Ser332/334 in the CaM-Binding C Terminus
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