Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women
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Summary
Tenofovir in a vaginal gel formulation shows significant protection against HIV infection in a randomized control trial, and could potentially fill an important HIV prevention gap, especially for women unable to successfully negotiate mutual monogamy or condom use.
- Type
- article
- Published
- 2010-07-19
- Cited by
- 2,516
- References
- 63
- Access
- Open access
- OpenAlex
- https://openalex.org/W1489950018
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6079353
Keywords
Microbicide, Tenofovir, Human immunodeficiency virus (HIV), Microbicides for sexually transmitted diseases, Medicine
References
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- Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: 18-month follow-up of the HIVNET 012 randomised trial.
- Safety and tolerability of tenofovir vaginal gel in abstinent and sexually active HIV-infected and uninfected women
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- Impact of improved treatment of sexually transmitted diseases on HIV infection in rural Tanzania: randomised controlled trial.
- Toward an information–motivation–behavioral skills model of microbicide adherence in clinical trials
- In Vitro and Ex Vivo Testing of Tenofovir Shows It Is Effective As an HIV-1 Microbicide
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- Preexposure Chemoprophylaxis for HIV Prevention in Men Who Have Sex with Men
- Randomized, Controlled Intervention Trial of Male Circumcision for Reduction of HIV Infection Risk: The ANRS 1265 Trial
- HIV prevention: the need for methods women can use.
Cited by
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- State of the art in intravaginal ring technology for topical prophylaxis of HIV infection.
- A comparative study of Smugel and KY Jelly vaginal lubricating gels
- Preexposure chemoprophylaxis for HIV prevention.
- Vaginally Administered PEGylated LIF Antagonist Blocked Embryo Implantation and Eliminated Non-Target Effects on Bone in Mice
- Human defensins 5 and 6 enhance HIV-1 infectivity through promoting HIV attachment
- Modeling the impact on the HIV epidemic of treating discordant couples with antiretrovirals to prevent transmission
- Male circumcision for HIV prevention: current evidence and implementation in sub-Saharan Africa
- Design and validation of a multiplexed low coherence interferometry instrument for in vivo clinical measurement of microbicide gel thickness distribution
- A natural theaflavins preparation inhibits HIV-1 infection by targeting the entry step: potential applications for preventing HIV-1 infection.
- HIV vaccines: an attainable goal?
- Development of polylactide and polyethylene vinyl acetate blends for the manufacture of vaginal rings.
- The cost-effectiveness of pre-exposure prophylaxis for HIV infection in South African women.
- 3-Hydroxyphthalic anhydride-modified human serum albumin as a microbicide candidate inhibits HIV infection by blocking viral entry.
- Preexposure prophylaxis (PrEP) of HIV infection in France: A nationwide cross-sectional study (PREVIC study)
- Overcoming Biological, Behavioral and Structural Vulnerabilities: New Directions in Research to Decrease HIV Transmission in Men who have Sex with Men
- Evaluation of microporous polycaprolactone matrices for controlled delivery of antiviral microbicides to the female genital tract
- Ratio of Monocytes to Lymphocytes in Peripheral Blood Identifies Adults at Risk of Incident Tuberculosis Among HIV-Infected Adults Initiating Antiretroviral Therapy
- Why vulnerable young women at risk of HIV should be prioritized for access to preexposure prophylaxis.
- Oral CCR5 inhibitors to prevent HIV transmission: the new "morning-before pill"?
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