Toll receptors in Drosophila: a family of molecules regulating development and immunity.
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Summary
The Toll receptor was originally identified and characterized for its role in the embryonic development of the fruit-fly Drosophila melanogaster and was also shown to be an essential component of the signaling pathway mediating the anti-fungal host defense in this model organism.
- Type
- review
- Published
- 2002-01-01
- Cited by
- 72
- References
- 84
- OpenAlex
- https://openalex.org/W1489949286
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:41128129
Keywords
Drosophila melanogaster, Biology, Receptor, Toll, Cell biology
References
- A Drosophila TNF-receptor-associated factor (TRAF) binds the ste20 kinase Misshapen and activates Jun kinase.
- Tissue-specific inducible expression of antimicrobial peptide genes in Drosophila surface epithelia.
- Insect immunity. A transgenic analysis in Drosophila defines several functional domains in the diptericin promoter.
- Functional analysis and regulation of nuclear import of dorsal during the immune response in Drosophila.
- Cutting Edge: The Toll Pathway Is Required for Resistance to Gram-Positive Bacterial Infections in Drosophila1
- The smallest known non-avian theropod dinosaur
- Crystal structure of a coagulogen, the clotting protein from horseshoe crab: a structural homologue of nerve growth factor.
- The Drosophila membrane receptor Toll can function to promote cellular adhesion.
- Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila.
- Interactions between the cellular and humoral immune responses in Drosophila.
- MyD88: an adapter that recruits IRAK to the IL-1 receptor complex.
- Genetic and molecular characterization of tube, a Drosophila gene maternally required for embryonic dorsoventral polarity.
- Cactus-independent regulation of Dorsal nuclear import by the ventral signal.
- The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein.
- A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense.
- Drosophila Toll and IL-1 receptor
- cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily.
- The spätzle gene encodes a component of the extracellular signaling pathway establishing the dorsal-ventral pattern of the Drosophila embryo.
- Lipopolysaccharide-activated Kinase, an Essential Component for the Induction of the Antimicrobial Peptide Genes inDrosophila melanogaster Cells*
- Toll signaling pathways in the innate immune response.
Cited by
- The multiple functions of the PGRP family in Drosophila immunity
- Understanding microglia-neuron cross talk: relevance of the microglia-neuron cocultures.
- The Innate Immune Response of Drosophila melanogaster against the Birnavirus Drosophila X Virus.
- Phagocytosis, a cellular immune response in insects
- Determinants of innate immune responses to mycobacteria
- The road to Toll
- Untersuchung des Einflusses von genetischen Polymorphismen des Toll-like-Rezeptors 4 auf Risiko/Prävalenz und Manifestation entzündlicher Parodontalerkrankungen
- Lamprey TLRs with Properties Distinct from Those of the Variable Lymphocyte Receptors1
- Drosophila melanogaster innate immunity: an emerging role for peptidoglycan recognition proteins in bacteria detection
- "Eat me" and "don't eat me" signals govern the innate immune response and tissue repair in the CNS: emphasis on the critical role of the complement system.
- Downregulation of lipopolysaccharide response in drosophila by negative crosstalk between the AP1 and NF-κB signaling modules
- Immunoglobulin superfamily members play an important role in the mosquito immune system.
- Coagulation in arthropods: defence, wound closure and healing.
- Regulators and signalling in insect haemocyte immunity.
- A coding mutation within the first exon of the human MD-2 gene results in decreased lipopolysaccharide-induced signaling
- Innate Immunity in a Pyralid Moth
- Hemolymph‐dependent and ‐independent responses in Drosophila immune tissue
- Sensing infection in Drosophila: Toll and beyond.
- Mechanisms of Gut Barrier Failure in the Pathogenesis of Necrotizing Enterocolitis: Toll Like Receptors Throw The Switch
- Spatial regulation of developmental signaling by a serpin.
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