Sources of the neurotoxin quinolinic acid in the brain of HIV-1-infected patients and retrovirus-infected macaques.
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Summary
A role for induction of indoleamine-2,3dioxygenase in accelerating the local formation of quinolinic acid within the brain tissue, particularly in areas of encephalitis, is demonstrated, rather than entry of quinsine into the brain from the meninges or blood.
- Type
- article
- Published
- 1998-07-01
- Cited by
- 157
- References
- 77
- OpenAlex
- https://openalex.org/W1484692085
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9532559
Keywords
Quinolinic acid, Kynurenine, Kynurenine pathway, Encephalitis, Macaque
References
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- Cerebrospinal Fluid Nitrite/Nitrate Levels in Neurologic Diseases
- Neuroinvasion by simian immunodeficiency virus coincides with increased numbers of perivascular macrophages/microglia and intrathecal immune activation.
- Quinolinic acid and neurodegeneration in AIDS.
- Stable isotope-labeled tryptophan as a precursor for studying the disposition of quinolinic acid in rabbits.
- Quinolinic acid in neurological disease: opportunities for novel drug discovery.
- 4-Chloro-3-hydroxyanthranilate, 6-chlorotryptophan and norharmane attenuate quinolinic acid formation by interferon-gamma-stimulated monocytes (THP-1 cells).
- A mechanism for increased quinolinic acid formation following acute systemic immune stimulation.
- Study of Receptor-Mediated Neurotoxins Released by HIV-1-Infected Mononuclear Phagocytes Found in Human Brain
- Poliovirus induces indoleamine‐2,3‐dioxygenase and quinolinic acid synthesis in macaque brain
- Different kynurenine pathway enzymes limit quinolinic acid formation by various human cell types.
- Human microglia convert l-tryptophan into the neurotoxin quinolinic acid.
- Relationship between interferon‐γ, indoleamine 2,3‐dioxygenase, and tryptophan catabolism
- Neuropharmacology of quinolinic and kynurenic acids.
- Cytopathologic and Neurochemical Correlates of Progression to Motor/Cognitive Impairment in SIV-lnfected Rhesus Monkeys
- A mechanism of quinolinic acid formation by brain in inflammatory neurological disease. Attenuation of synthesis from L-tryptophan by 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate.
- Neuropeptides in the sympathetic system: Presence, plasticity, modulation, and implications
- Human immunodeficiency virus type 1–infected monocytic cells can destroy human neural cells after cell‐to‐cell adhesion
- Immunologic NO Synthase: Elevation in Severe AIDS Dementia and Induction by HIV-1 gp41
- Kynurenine 3-hydroxylase in brain: species activity differences and effect of gerbil cerebral ischemia.
Cited by
- The mechanisms of neuronal damage in retroviral infections of the nervous system.
- Excitotoxic degeneration of hypothalamic orexin neurons in slice culture.
- Cellular interplay between neurons and glia: toward a comprehensive mechanism for excitotoxic neuronal loss in neurodegeneration.
- 5 Kynurenines in the Brain: Preclinical and Clinical Studies, Therapeutic Considerations
- Kynurenine metabolism in central nervous system in experimental chronic renal failure.
- RELATIONSHIP BETWEEN SYSTEMIC AND CENTRAL NERVOUS SYSTEM MONOCYTE/MACROPHAGE INFECTION IN SIMIAN IMMUNODEFICIENCY VIRUS ENCEPHALITIS
- Immunologische Aspekte bei depressiven Störungen
- The Mechanisms of Neuronal Damage in Virus Infections of the Nervous System
- Kynurenines in neurodegenerative disorders: therapeutic consideration.
- A psychoneuroimmunological perspective to Emil Kraepelins dichotomy
- Studies on experimental neonatal CNS infection : Implications for neuropsychiatric disorders
- Antioxidants Inhibit Indoleamine 2,3-Dioxygenase in IFN-γ-Activated Human Macrophages: Posttranslational Regulation by Pyrrolidine Dithiocarbamate1
- An investigation of neurochemical, structural and functional characteristics in the murine model of collagen induced arthritis
- Efeito in vitro de quinureninas sobre vários parâmetros de estresse oxidativo em córtex cerebral de ratos jovens
- Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection
- Effects of systemic and central nervous system localized inflammation on the contributions of metabolic precursors to the l‐kynurenine and quinolinic acid pools in brain
- The role of kynurenines in the production of neuronal death, and the neuroprotective effect of purines
- Kynurenine Pathway Metabolites in Humans: Disease and Healthy States
- Dysregulation of the kynurenine pathway in psychotic disorders : immunological aspects
- Dysregulation of tryptophan metabolism in a sub-Saharan HIV/AIDS population
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