Sources of the neurotoxin quinolinic acid in the brain of HIV-1-infected patients and retrovirus-infected macaques.

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Summary

A role for induction of indoleamine-2,3dioxygenase in accelerating the local formation of quinolinic acid within the brain tissue, particularly in areas of encephalitis, is demonstrated, rather than entry of quinsine into the brain from the meninges or blood.

Type
article
Published
1998-07-01
Cited by
157
References
77

Keywords

Quinolinic acid, Kynurenine, Kynurenine pathway, Encephalitis, Macaque

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