Melatonin inhibits the Migration of Colon Cancer RKO cells by Down-regulating Myosin Light Chain Kinase Expression through Cross-talk with p38 MAPK.
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Summary
Melatonin could inhibit the proliferation and migration of RKO cells, and further experiments confirmed that p38 MAPK plays an important role in regulating melatonin-induced migration inhibition through down-regulating the expression and activity of MLCK.
- Type
- article
- Published
- 2015-09-02
- Cited by
- 36
- References
- 60
- Access
- Open access
- OpenAlex
- https://openalex.org/W1238221767
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:27658872
Keywords
Melatonin, Myosin light-chain kinase, p38 mitogen-activated protein kinases, Immunoglobulin light chain, MAPK/ERK pathway
References
- Myosin Light Chain Kinase Inhibitors Can Block Invasion and Adhesion of Human Pancreatic Cancer Cell Lines
- Caspase activation during phorbol ester-induced apoptosis requires ROCK-dependent myosin-mediated contraction
- Melatonin potentiates the antiproliferative and pro‐apoptotic effects of ursolic acid in colon cancer cells by modulating multiple signaling pathways
- Melatonin suppresses migration and invasion via inhibition of oxidative stress pathway in glioma cells
- Cytoskeletal mechanisms responsible for invasive migration of neoplastic cells.
- Melatonin, sleep disturbance and cancer risk.
- An increase or a decrease in myosin II phosphorylation inhibits macrophage motility
- Synthesis and pro-apoptotic effects of new sulfonamide derivatives via activating p38/ERK phosphorylation in cancer cells
- p38α MAPK pathway: a key factor in colorectal cancer therapy and chemoresistance.
- Baicalein inhibits the invasion of gastric cancer cells by suppressing the activity of the p38 signaling pathway.
- Melatonin suppresses AOM/DSS-induced large bowel oncogenesis in rats.
- A novel all-trans retinoid acid derivatives inhibits the migration of breast cancer cell lines MDA-MB-231 via myosin light chain kinase involving p38-MAPK pathway.
- Myosin IIA regulates cell motility and actomyosin–microtubule crosstalk
- Pro-oncogenic role of alternative p38 mitogen-activated protein kinases p38γ and p38δ, linking inflammation and cancer in colitis-associated colon cancer.
- Expression of subtype-specific Group 1 leiomyosarcoma markers in a wide variety of sarcomas by gene expression analysis and immunohistochemistry
- Melatonin induces apoptotic death in LNCaP cells via p38 and JNK pathways: therapeutic implications for prostate cancer
- Melatonin potentiates flavone‐induced apoptosis in human colon cancer cells by increasing the level of glycolytic end products
- Gastrin induces over-expression of genes involved in human U373 glioblastoma cell migration
- SIRT1/PGC1α-Dependent Increase in Oxidative Phosphorylation Supports Chemotherapy Resistance of Colon Cancer
- Melatonin Inhibits the Migration of Human Lung Adenocarcinoma A549 Cell Lines Involving JNK/MAPK Pathway
Cited by
- Comparison of gene expression profiles in aortic dissection and normal human aortic tissues
- Melatonin as a promising agent of regulating stem cell biology and its application in disease therapy.
- Myosin light chain kinase MYLK1: Anatomy, interactions, functions, and regulation
- 6‐Gingerol protects intestinal barrier from ischemia/reperfusion‐induced damage via inhibition of p38 MAPK to NF‐&kgr;B signalling
- Effects of Melatonin Suplementation in Human Pathologie: A Systematic Review
- Evaluation of cell death pathways initiated by antitumor drugs melatonin and valproic acid in bladder cancer cells
- The Impact of Melatonin on Colon Cancer Cells’ Resistance to Doxorubicin in an In Vitro Study
- Melatonin inhibits colon cancer RKO cell migration by downregulating Rho-associated protein kinase expression via the p38/MAPK signaling pathway
- Melatonin reduces apoptotic cells, SOD2 and HSPB1 and improves the in vitro production and quality of bovine blastocysts
- Insights on melatonin as an active pharmacological molecule in cancer prevention: what's new?
- MYLK promotes hepatocellular carcinoma progression through regulating cytoskeleton to enhance epithelial–mesenchymal transition
- Protective and therapeutic potential of ginger (Zingiber officinale) extract and [6]‐gingerol in cancer: A comprehensive review
- Ulinastatin attenuates liver injury and inflammation in a cecal ligation and puncture induced sepsis mouse model
- Non-target Genes Regulate miRNAs-Mediated Migration Steering of Colorectal Carcinoma
- Androgen receptor variant 12 promotes migration and invasion by regulating MYLK in gastric cancer
- The emergence of melatonin in oncology: Focus on colorectal cancer
- Melatonin as a potential inhibitor of colorectal cancer: Molecular mechanisms
- The potential therapeutic actions of melatonin in colorectal cancer
- Melatonin: An important anticancer agent in colorectal cancer
- Therapeutic Opportunities in Colorectal Cancer: Focus on Melatonin Antioncogenic Action
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