The human CD34 hematopoietic stem cell antigen promoter and a 3' enhancer direct hematopoietic expression in tissue culture.
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Summary
It is shown here that the CD34 gene is transcriptionally regulated in tissue culture cells and should provide a means to direct the expression of heterologous genes in hematopoietic stem cells and progenitors.
- Type
- article
- Published
- 1992-12-15
- Cited by
- 49
- References
- 53
- Access
- Open access
- OpenAlex
- https://openalex.org/W1216602061
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1070179
Keywords
Biology, CD34, Stem cell, Molecular biology, Progenitor cell
References
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- An enhancer located in a CpG‐island 3′ to the TCR/CD3‐epsilon gene confers T lymphocyte‐specificity to its promoter.
- Optimization of transient transfection into human myeloid cell lines using a luciferase reporter gene.
- Antigenic analysis of hematopoiesis. V. Characterization of My-10 antigen expression by normal lymphohematopoietic progenitor cells.
- Expression of the CD34 gene in vascular endothelial cells.
- Localization of hematopoietic progenitor cells in tissue with the anti-My-10 monoclonal antibody.
- CD34 expression by stromal precursors in normal human adult bone marrow.
- A new hematopoietic cell line, KMT-2, having human interleukin-3 receptors.
- Effects of recombinant human interleukin-3 on CD34-enriched normal hematopoietic progenitors and on myeloblastic leukemia cells.
- Identification of enhancer sequences 3' of the rabbit Ig kappa L chain loci.
- Characterization of tissue-specific enhancer elements in the second intron of the human apolipoprotein B gene.
- In vitro methylation of the promoter and enhancer of Pro alpha 1(I) collagen gene leads to its transcriptional inactivation.
- Regulation of the gene for CD34, a human hematopoietic stem cell antigen, in KG-1 cells.
- Activated protein kinase C directly phosphorylates the CD34 antigen on hematopoietic cells.
- Functional analysis of the endothelin-1 gene promoter. Evidence for an endothelial cell-specific cis-acting sequence.
- Human transcription factor GATA-2. Evidence for regulation of preproendothelin-1 gene expression in endothelial cells.
- Transcripts from the Cellular Homologs of Retroviral Oncogenes: Distribution Among Chicken Tissues
- Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells.
- Characterization of adult human marrow hematopoietic progenitors highly enriched by two-color cell sorting with My10 and major histocompatibility class II monoclonal antibodies.
- Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells.
Cited by
- Expression of endothelial cell adhesion molecules on heart valves: up‐regulation in degeneration as well as acute endocarditis
- Nucleolin Regulates Gene Expression in CD34-positive Hematopoietic Cells*
- A nuclear factor Y (NFY) site positively regulates the human CD34 stem cell gene.
- Bone regeneration in critical-size calvarial defects using human dental pulp cells in an extracellular matrix-based scaffold.
- Human eosinophil Charcot-Leyden crystal protein: cloning and characterization of a lysophospholipase gene promoter.
- Transcriptional regulation during myelopoiesis
- Transcriptional regulation and chromatin structure of the human CD34 gene promoter region.
- CD34: structure, biology, and clinical utility.
- Transcription factors, normal myeloid development, and leukemia.
- Control of AC133/CD133 and impact on human hematopoietic progenitor cells through nucleolin
- The myeloid zinc finger gene, MZF-1, regulates the CD34 promoter in vitro.
- A cell proliferation-dependent multiprotein complex NC-3A positively regulates the CD34 promoter via a TCATTT-containing element.
- Evaluación de la capacidad de osteodiferenciación de células madre mensenquimales aisladas de pulpa y ligamento periodontal utilizando diferentes medios de inducción
- A role of nucleolin in human hematopoietic progenitor cells
- Rb and nucleolin antagonize in controlling human CD34 gene expression.
- Acute myelomonoblastic leukemia carrying the PEBP2beta/MYH11 fusion gene.
- c-Myb acetylation at the carboxyl-terminal conserved domain by transcriptional co-activator p300
- Identification and Characterization of a Functional Promoter Region in the Human Eosinophil IL-5 Receptor Subunit Gene (*)
- Chemoprotection of normal tissues by transfer of drug resistance genes
- Characterization of the human myeloid cell nuclear differentiation antigen gene promoter.
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