Chronic Fatigue Syndrome and DNA Hypomethylation of the Glucocorticoid Receptor Gene Promoter 1F Region: Associations With HPA Axis Hypofunction and Childhood Trauma
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Summary
Evidence of NR3C1 promoter hypomethylation in female patients with CFS is found and the functional relevance of these differences was consistent with the hypothalamic-pituitary-adrenalaxis hypofunction hypothesis (GR hypersuppression).
- Type
- article
- Published
- 2015-10-01
- Cited by
- 43
- References
- 47
- OpenAlex
- https://openalex.org/W1136951987
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:27189682
Keywords
Glucocorticoid receptor, DNA methylation, CpG site, Methylation, Internal medicine
References
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- Childhood trauma and risk for chronic fatigue syndrome: association with neuroendocrine dysfunction.
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- Epigenetics in mood disorders
- The combined dexamethasone/CRH test: a refined laboratory test for psychiatric disorders.
- Conditions Comorbid with Chronic Fatigue in a Population-Based Sample
- Epigenomic Mechanisms of Early Adversity and HPA Dysfunction: Considerations for PTSD Research
- The Comorbidity of Self-Reported Chronic Fatigue Syndrome, Posttraumatic Stress Disorder, and Traumatic Symptoms
- The American College of Rheumatology Preliminary Diagnostic Criteria for Fibromyalgia and Measurement of Symptom Severity
- Pharmacological and Nonpharmacological Factors Influencing Hypothalamic–Pituitary–Adrenocortical Axis Reactivity in Acutely Depressed Psychiatric In-patients, Measured by the Dex-CRH Test
Cited by
- Altered neuroendocrine control and association to clinical symptoms in adolescent chronic fatigue syndrome: a cross-sectional study
- Childhood abuse, promoter methylation of leukocyte NR3C1 and the potential modifying effect of emotional support.
- Suboptimal nutrition in early life affects the inflammatory gene expression profile and behavioral responses to stressors.
- Stress, burnout and depression: A systematic review on DNA methylation mechanisms.
- Epigenetic Pathways in Human Disease: The Impact of DNA Methylation on Stress-Related Pathogenesis and Current Challenges in Biomarker Development
- The European ME/CFS Biomarker Landscape project: an initiative of the European network EUROMENE
- Differential effects of childhood trauma subtypes on fatigue and physical functioning in chronic fatigue syndrome.
- Depression, Evening Salivary Cortisol and Inflammation in Chronic Fatigue Syndrome: A Psychoneuroendocrinological Structural Regression Model
- Glucocorticoid receptor DNA methylation and childhood trauma in chronic fatigue syndrome patients.
- Transforming growth factor beta (TGF-β) in adolescent chronic fatigue syndrome
- Infection Elicited Autoimmunity and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: An Explanatory Model
- Couple-Based Stress Management Intervention and Chronic Fatigue Syndrome (CFS) Biopsychological Processes
- Reduction of Glucocorticoid Receptor Function in Chronic Fatigue Syndrome
- Identification of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-associated DNA methylation patterns
- Glucocorticoid receptor gene (NR3C1) DNA methylation in association with trauma, psychopathology, transcript expression, or genotypic variation: A systematic review
- Epigenetic Inheritance: Concepts, Mechanisms and Perspectives
- Childhood Trauma, DNA Methylation of Stress-related Genes, and Depression: Findings from Two Monozygotic Twin Studies
- Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?
- Epigenetic Components of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Uncover Potential Transposable Element Activation.
- Network structure underpinning (dys)homeostasis in chronic fatigue syndrome; Preliminary findings
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