Prevention Studies in Alzheimer’s Disease: Progress Towards the Development of New Therapeutics
Explore this paper's citation graph
Summary
An overview of trials testing pharmacological interventions for sporadic AD prevention is presented, a major shift has taken place in the methodology of AD prevention trials since the results of the first trials were published in the 1990s.
- Type
- article
- Published
- 2015-07-19
- Cited by
- 8
- References
- 101
- Access
- Open access
- OpenAlex
- https://openalex.org/W1036708247
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:365651
Keywords
Disease, Medicine, Dementia, Clinical trial, Population
References
- Vitamin E and donepezil for the treatment of mild cognitive impairment.
- Antihypertensive medication use and incident Alzheimer disease: the Cache County Study.
- The rise and fall of Dimebon
- Naproxen and celecoxib do not prevent AD in early results from a randomized controlled trial
- Biomarkers in Alzheimer's Disease
- Methodological Issues in Primary Prevention Trials for Neurodegenerative Dementia
- Study design of ASPirin in Reducing Events in the Elderly (ASPREE): a randomized, controlled trial
- Preclinical trials in autosomal dominant AD: Implementation of the DIAN-TU trial
- A Critique of the Drug Discovery and Phase 3 Clinical Programs Targeting the Amyloid Hypothesis for Alzheimer Disease
- Effects of blood pressure lowering with perindopril and indapamide therapy on dementia and cognitive decline in patients with cerebrovascular disease.
- Calcium Channel Blockers and Alzheimer's Disease: Potential Relevance in Treatment Strategies of Metabolic Syndrome
- Alzheimer's Prevention Initiative
- Preventing Alzheimer's disease and cognitive decline.
- Effect of pioglitazone medication on the incidence of dementia
- Testing the Right Target and the Right Drug at the Right Stage
- The use of pioglitazone and the risk of bladder cancer in people with type 2 diabetes: nested case-control study
- Beyond Amyloid: Getting Real about Non-Amyloid Targets in Alzheimer’s Disease
- Efficacy of antibody-based therapies to treat Alzheimer's disease: just a matter of timing?
- Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial.
- Therapeutic potential of statins in Alzheimer's disease.
Cited by
- Prophylactic immunotherapy of Alzheimer's disease using recombinant amyloid-β B-cell epitope chimeric protein as subunit vaccine
- Improved synaptic and cognitive function in aged 3 × Tg-AD mice with reduced amyloid-β after immunotherapy with a novel recombinant 6Aβ15-TF chimeric vaccine.
- Current status and future prospects of stem cell therapy in Alzheimer’s disease
- The prevalence of Alzheimer’s disease in the Chinese Han population: a meta-analysis
- Recent advances and current perspectives in treatment of Alzheimer’s disease
- Robust EEG Based Biomarkers to Detect Alzheimer’s Disease
- Potential Implication of Treatments for Alzheimer’s Disease: Current and Future
- A dose–response meta-analysis of physical activity and the risk of alzheimer’s disease in prospective studies
- Potential Implication of Treatments for Alzheimers disease: Current and Future
Related papers
- [The incidence of reversible dementia in 145 patients referred on suspicion of dementia].
- Dementia risk prediction: are we there yet?
- Analyzing the chance of developing dementia among geriatric people: a cross‐sectional pilot study in Bangladesh
- Challenges of diagnosing dementia in the oldest old population.
- Survey of Dementia Awareness and Needs in Seongdong-gu Regional Center for Dementia
- Reversible dementia and the misdiagnosis of dementia: a review.
- Recruitment of Subjects Into Clinical Trials for Alzheimer Disease
- Phase 0 clinical trials will overcome stagnation of anticancer drug development?
- Progress in development of disease-modifying treatments in Parkinson's Disease