Early-Life Adversity and Physical and Emotional Health across the Lifespan: A Neuro-Immune Network Hypothesis
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Summary
It is argued that early-life adversity amplifies crosstalk between peripheral inflammation and neural circuitries subserving threat-, reward-, and executive control-related processes, which results in chronic low-grade inflammation, thereby contributing to adiposity, insulin resistance, and other predisease states.
- Type
- review
- Published
- 2015-06-04
- Cited by
- 608
- References
- 151
- Access
- Open access
- OpenAlex
- https://openalex.org/W922914407
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:3527754
Keywords
Stressor, Psychology, Vulnerability (computing), Mental health, Developmental psychology
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Cited by
- The Role of Adverse Childhood Experiences in Cardiovascular Disease Risk: a Review with Emphasis on Plausible Mechanisms
- Evidence of an IFN-γ by early life stress interaction in the regulation of amygdala reactivity to emotional stimuli.
- Links between inflammation, amygdala reactivity, and social support in breast cancer survivors
- Cumulative stress in childhood is associated with blunted reward-related brain activity in adulthood.
- Hidden Wounds? Inflammatory Links Between Childhood Trauma and Psychopathology
- Neuro‐, Cardio‐, and Immunoplasticity: Effects of Early Adversity
- PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO GRANDE DO SUL FACULDADE DE PSICOLOGIA PROGRAMA DE PÓS-GRADUAÇÃO EM PSICOLOGIA
- Parental Support Buffers the Association of Depressive Symptoms with Cortisol and C-Reactive Protein during Adolescence
- The impact of poor diet and early life stress on memory status
- Psychological and neurophysiological mechanisms of the intergenerational transmission of dysfunctional parenting
- Association of serum interleukin-6 with mental health problems in children exposed to perinatal complications and social disadvantage.
- Developing Comprehensive Models of the Effects of Stress and Trauma on Biology, Brain, Behavior, and Body
- Crack cocaine addiction, early life stress and accelerated cellular aging among women.
- Psychological resilience and the gene regulatory impact of posttraumatic stress in Nepali child soldiers
- Inflammation Effects on Motivation and Motor Activity: Role of Dopamine
- Distinct behavioral and immunoendocrine parameters during crack cocaine abstinence in women reporting childhood abuse and neglect.
- Major depressive disorder
- The relationship between parents’ social network diversity and pulmonary function among children with asthma
- Die Bedeutung früher traumatischer Lebenserfahrungen
- Testing the biological embedding hypothesis: Is early life adversity associated with a later proinflammatory phenotype?
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