NMR studies of the structure, kinetics and interactions of the conserved RNA motifs in the FMDV IRES.

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Summary

Analysis of the 16mer apo-RNA and its Mg2+ RNA complex NMR solution structures revealed that Mg1+-induced structural changes to the GUAA tetraloop act to stabilise the loop via stronger base stacking and intramolecular interactions.

Published
2012-06-16
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