The Role of U2AF1 Mutations in the Pathogenesis of Myelodysplastic Syndromes
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Summary
It is suggested that mutant U2AF1 expression contributes to the altered hematopoiesis and pre-mRNA splicing observed in patients with U2 AF1 mutations.
- Published
- 2014-10-01
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- 0
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- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:82707707
References
- Patterns of missplicing due to somatic U2AF1 mutations in myeloid neoplasms.
- Mutant U2AF1 Expression Alters Hematopoiesis In Transgenic Mice
- Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia
- Mutant U2AF1 Expression Alters Hematopoiesis and Pre-mRNA Splicing In Vivo
- Functional recognition of the 3′ splice site AG by the splicing factor U2AF35
- Intramedullary apoptosis of hematopoietic cells in myelodysplastic syndrome patients can be massive: apoptotic cells recovered from high-density fraction of bone marrow aspirates.
- MacroH2A histone variants act as a barrier upon reprogramming towards pluripotency
- Mutations affecting mRNA splicing define distinct clinical phenotypes and correlate with patient outcome in myelodysplastic syndromes.
- Simultaneous assessment of cell kinetics and programmed cell death in bone marrow biopsies of myelodysplastics reveals extensive apoptosis as the probable basis for ineffective hematopoiesis
- U2AF1 Mutations Alter Sequence Specificity of pre-mRNA Binding and Splicing
- Clinical and biological implications of driver mutations in myelodysplastic syndromes.
- Epidemiology of Myelodysplastic Syndromes
- PICALM-MLLT10 acute myeloid leukemia: a French cohort of 18 patients.
- A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q− syndrome
- Mutational landscape and significance across 12 major cancer types
- Landscape of genetic lesions in 944 patients with myelodysplastic syndromes
- Mechanisms of genome instability induced by RNA processing defects
- Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo.
- A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity
- The histone variant macroH2A is an epigenetic regulator of key developmental genes
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