The structure and function of cartilage proteoglycans.
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Summary
The structure/function relationships of the cartilage proteoglycans are discussed, and the manner in which perturbations in proteoglycan structure or abundance can adversely affect tissue function is discussed.
- Type
- review
- Published
- 2006-11-30
- Cited by
- 424
- References
- 79
- Access
- Open access
- OpenAlex
- https://openalex.org/W345774991
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10262715
Keywords
Biglycan, Lumican, Aggrecan, Decorin, Proteoglycan
References
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- Presence of pro-forms of decorin and biglycan in human articular cartilage.
- Structure of the human aggrecan gene: exon-intron organization and association with the protein domains.
- Binding of fibromodulin and decorin to separate sites on fibrillar collagens.
- Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in mice
- Isolation and characterization of disulfide-bonded peptides from the three globular domains of aggregating cartilage proteoglycan.
- cDNA cloning of chick cartilage chondroitin sulfate (aggrecan) core protein and identification of a stop codon in the aggrecan gene associated with the chondrodystrophy, nanomelia.
- Mice lacking link protein develop dwarfism and craniofacial abnormalities
- Dermatan sulphate proteoglycans of human articular cartilage. The properties of dermatan sulphate proteoglycans I and II.
- The heterogeneity of link proteins isolated from human articular cartilage proteoglycan aggregates.
- Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human-specific repeats, and additional alternatively spliced forms.
- Expression of alternatively spliced epidermal growth factor-like domains in aggrecans of different species. Evidence for a novel module.
- The primary structure of the core protein of the small, leucine-rich proteoglycan (PG I) from bovine articular cartilage.
- Structures of N-linked and O-linked oligosaccharides on proteoglycan monomer isolated from the Swarm rat chondrosarcoma.
- Age-related changes in the structure of proteoglycan link proteins present in normal human articular cartilage.
- Hyaluronic acid in human articular cartilage. Age-related changes in content and size.
- Mouse cartilage matrix deficiency (cmd) caused by a 7 bp deletion in the aggrecan gene
- The human decorin gene: intron-exon organization, discovery of two alternatively spliced exons in the 5' untranslated region, and mapping of the gene to chromosome 12q23.
- Congenital stromal dystrophy of the cornea caused by a mutation in the decorin gene.
- A Human-specific Polymorphism in the Coding Region of the Aggrecan Gene
Cited by
- Growth and differentiation of prechondrogenic cells on bioactive self-assembled peptide nanofibers.
- The morphology and histology study on rabbit degenerated medial meniscus after posterior cruciate ligament rupture
- Cartilage Lubrication and Joint Protection by the Glycoprotein PRG4 Studied on the Microscale
- The Effects of Designed Scaffold Architecture and Biodegradable Material on Chondrogenesis in vitro and in vivo.
- Effets de perturbateurs endocriniens sur le développement du squelette
- Regional comparisons of nano-mechanical properties of the human meniscus; structure and function
- On the role of signaling pathways in the pathogenesis of osteoarthritis
- In vitro cultivation of adult human chondrocytes : importance of culture system, oxygen and zonal differences
- Bone and Cartilage Regeneration: Wnt Signaling Pathway in Healing
- Osteogenesis Imperfecta Type I-IV, the Collagenous Disorder of Connective Tissue in Czech Population
- Caractérisation des interactions glycosaminoglycannes/protéines dans le but de développer des molécules d'intérêt thérapeutique : exemples de l'Endocan et de l'interféron gamma
- Feasibility of agent-based modelling of articular cartilage including a conceptual representation of its structure
- Biochemical and mechanical stimuli for improved material properties and preservation of tissue-engineered cartilage
- Static compressive stress induces mitochondrial oxidant production in articular cartilage
- Development of zonal cartilage constructs : effects of chondrocyte subpopulation, compressive stimulation, and culture models
- Potential role of cathepsin K in the pathophysiology of mucopolysaccharidoses
- Nutraceuticals in the Management of Osteoarthritis
- Rôle des glucosaminyl sulfotransférases dans la biosynthèse de motifs héparanes sulfates impliqués dans la fixation et l’activité de facteurs inflammatoires
- Self-assembled octapeptide gels for cartilage repair
- Chitosan fibrous scaffolds for cartilage tissue engineering
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