Pharmacokinetic Analysis and Antiepileptic Activity of Tetra-Methylcyclopropane Analogues of Valpromide

Keywords

Pharmacokinetics, Tetra, Chemistry, Pharmacology, Anticonvulsant

References

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• Pharmacokinetic Analysis of the Structural Requirements for Forming “Stable” Analogues of ValpromideAbdulla Haj-Yehia, Salim Hadad, Meir Bialer — 1992
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• Severe Hepatotoxicity During Valproate Therapy: An Update and Report of Eight New FatalitiesArmin König, H. Siemes, F Bläker — 1994
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• 1-aminocyclopropanecarboxylates exhibit antidepressant and anxiolytic actions in animal models.Ramón Trullás, Traci Folio, Andrew W. Young — 1991
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• Noncompartmental determination of the steady-state volume of distribution.Leslie Z. Benet, Renato L. Galeazzi — 1979
• Valproate‐Induced Hepatic Injury: Analyses of 23 Fatal CasesHyman J. Zimmerman, Kamal G. Ishak — 2007
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• Statistical moments in pharmacokineticsKiyoshi Yamaoka, Terumichi Nakagawa, Toyozo Uno — 1978
• Structure-pharmacokinetic relationships in a series of short fatty acid amides that possess anticonvulsant activity.Abdulla Haj-Yehia, Meir Bialer — 1990
• 1-Aminocyclopropane-1-carboxylic acid (ACC) mimics the effects of glycine on the NMDA receptor ion channel.Varda Nadler, Yoel Kloog, Mordechai Sokolovsky — 1988
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• Valproic acid teratogenesisHeinz Nau — 1987

Cited by

• Theoretical characterization of SOME amides and esters DERIVATIVES of valproic acid城介 天田 — 2010
• Comparative pharmacodynamic and pharmacokinetic analysis of two anticonvulsant halo derivatives of 2,2,3,3‐tetramethylcyclopropanecarboxamide, an amide of a cyclic analog of valproic acidNeta Pessah, Dan Kaufmann, Boris Yagen — 2010
• Structure Activity Relationship of Human Microsomal Epoxide Hydrolase Inhibition by Amide and Acid Analogues of Valproic AcidOfer Spiegelstein, Deanna L. Kroetz, René H. Levy — 2000
• Pharmacokinetics and Antiepileptic Activity of Valproyl Hydroxamic Acid DerivativesMicha Levi, Boris Yagen, Meir Bialer — 1997
• Efficacy of antiepileptic tetramethylcyclopropyl analogues of valproic acid amides in a rat model of neuropathic pain.Ilan Winkler, Eyal Sobol, Boris Yagen — 2005
• Propylisopropylacetic acid (PIA), a constitutional isomer of valproic acid, uncompetitively inhibits arachidonic acid acylation by rat acyl-CoA synthetase 4: a potential drug for bipolar disorderHiren R. Modi, Mireille Basselin, Ameer Y. Taha — 2013
• Characterization of the anticonvulsant profile of valpromide derivatives.Silvina M. Tasso, S.C. Moon, Luis E. Bruno‐Blanch — 2004
• Valproic acid: Second generationMeir Bialer, Boris Yagen — 2011
• Anticonvulsant efficacy of valproate-like carboxylic acids: a potential target for anti-bipolar therapy.Abed N. Azab, Miriam L. Greenberg — 2007
• Anticonvulsant Profile and Teratogenicity of N‐methyl‐tetramethylcyclopropyl Carboxamide: A New Antiepileptic DrugNina Isoherranen, H. Steve White, Richard H. Finnell — 2002
• New CNS-active drugs which are second-generation valproic acid: can they lead to the development of a magic bullet?Nina Isoherranen, Boris Yagen, Meir Bialer — 2003
• The Effects of Central Nervous System-Active Valproic Acid Constitutional Isomers, Cyclopropyl Analogs, and Amide Derivatives on Neuronal Growth Cone BehaviorJakob A. Shimshoni, Emma Dalton, A. Varanou Jenkins — 2007
• Valproate decreases inositol biosynthesis.Galit Shaltiel, Alon Shamir, Joseph Shapiro — 2004
• Metabolism of a new antiepileptic drug, N-methyl-tetramethylcyclopropanecarboxamide, and anticonvulsant activity of its metabolites.Nina Isoherranen, René H. Levy, Boris Yagen — 2004
• New CNS-active drugs which are second-generation valproic acidNina Isoherranen, Boris Yagen, Meir Bialer — 2003
• Pulmonary and general pharmacokinetic studies on racemic ethosuximide using a chiral sensitive GC/MS technique.Lino Sghendo — 2002
• Developing an in vitro model of haemorrhagic shock to investigate the molecular mechanism of valproic acid in the treatment of massive blood lossAlexandra M.E. Zuckermann — 2015
• Insights into Structural Modifications of Valproic Acid and Their Pharmacological ProfileManish Mishra, Samiksha Kukal, Priyanka Rani Paul — 2021
• Valproic acid as a therapeutic scaffold: Advances in structural modification and drug design.Aleksandra Trocha, Dorota G. Piotrowska, Magdalena Markowicz-Piasecka — 2025
• SYNTHESIS AND ANTICONVULSANT STUDIES OF ISOMERIC N-BENZYL-3- ((METHYLPHENYL) AMINO) PROPANAMIDESÎ. Ay — 2010

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