A kinetic model of the circulatory regulation of tissue plasminogen activator during exercise, epinephrine infusion, and endurance training.
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Summary
A computer simulation of the circulatory system was used to kinetically model secretion, inhibition, and clearance of tissue plasminogen activator (t-PA) during three different processes that increase active t-PA levels: epinephrine infusion, exercise, and endurance training.
- Type
- article
- Published
- 1993-06-15
- Cited by
- 49
- References
- 44
- Access
- Open access
- OpenAlex
- https://openalex.org/W305791279
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2859862
Keywords
Epinephrine, Internal medicine, Endocrinology, Plasminogen activator, Secretion
References
- Optimum conditions for the stabilization and measurement of tissue plasminogen activator activity in human plasma.
- Characterization of the dexamethasone-induced inhibitor of plasminogen activator in HTC hepatoma cells.
- Mechanisms and quantitative assessment of drug effects on cardiac output with a new model of the circulation.
- Comparison of double- and single-isotope enzymatic derivative methods for measuring catecholamines in human plasma.
- Hepatic vascular bed.
- Standardization of methods for measuring plasminogen activator inhibitor activity in human plasma.
- A critical review of the relationship between impaired fibrinolysis and myocardial infarction.
- Hepatic clearance and liver blood flow.
- Diurnal variation of tissue-type plasminogen activator and its rapid inhibitor (PAI-1).
- The effect of adrenaline and noradrenaline on hepatic blood flow and splanchnic carbohydrate metabolism in man
- Correlations between t-PA and PAI-1 antigen and activity and t-PA/PAI-1 complexes in plasma of control subjects and of patients with increased t-PA or PAI-1 levels.
- Radionuclide-determined change in pulmonary blood volume with exercise. Improved sensitivity of multigated blood-pool scanning in detecting coronary-artery disease.
- Plasma Plasminogen Activator Inhibitor‐1 in Angina Pectoris: Influence of Plasma Insulin and Acute‐phase Response
- Extrinsic plasminogen activator response to exercise after a single dose of propranolol.
- Life style and blood fibrinolytic activity: a comment on clearance of plasminogen activators
- Pharmacokinetics and isolated liver perfusion of carbohydrate modified recombinant tissue-type plasminogen activator
- Effect of adrenaline on exchange of free fatty acids in leg tissues and splanchnic area. A comparison with the metabolic response to surgical stress.
- Effects of Physical Conditioning on Fibrinolytic Variables and Fibrinogen in Young and Old Healthy Adults
- Kinetic analysis of the interactions between plasminogen activator inhibitor 1 and both urokinase and tissue plasminogen activator.
- Pathologic Fibrinolysis as a Cause of Clinical Bleeding
Cited by
- Strategies to reduce hemostatic activation during cardiopulmonary bypass.
- Plasma von Willebrand factor, tissue plasminogen activator, plasminogen activator inhibitor, and antithrombin III levels in Behçet's disease.
- The effect of external pneumatic compression on regional fibrinolysis in a prospective randomized trial.
- Clearance of tissue plasminogen activator (TPA) and TPA/plasminogen activator inhibitor type 1 (PAI-1) complex: relationship to elevated TPA antigen in patients with high PAI-1 activity levels.
- Constitutive synthesis of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAT-1): Conditions and therapeutic targets
- Enhancement of PAI-1 mRNA in cardiovascular cells after kainate injection is mediated through the sympathetic nervous system.
- Parallel Analysis of Tissue‐Type Plasminogen Activator and Type 1 Plasminogen Activator Inhibitor in Plasma and Endothelial Cells Derived From Patients With Chronic Pulmonary Thromboemboli
- Endothelium in hemostasis and thrombosis.
- Changes in thrombolytic and inflammatory markers after initiation of indinavir- or amprenavir-based antiretroviral therapy
- Altered interaction between plasminogen activator inhibitor type 1 activity and sympathetic nerve activity with aging.
- The human fibrinolytic system.
- Fibrinolytic activity is not dependent upon exercise mode in post-myocardial infarction patients
- Lessons from the aprotinin saga: current perspective on antifibrinolytic therapy in cardiac surgery
- Exercise-induced tissue plasminogen activator increase: a role for metabolic acidosis
- Secretion of tissue plasminogen activator and plasminogen activator inhibitor 1 during cardiopulmonary bypass.
- Effects of sympathetic activation by adrenergic infusions on hemostasis in vivo
- The effect of submaximal exercise on fibrinolysis
- Progress in clinical fibrinolysis
- Regionally differentiated fibrinolytic responses during volume‐resuscitated acute endotoxemia in pigs
- Swimming and hemostasis during rehabilitation in patients with coronary heart disease.
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