A mechanism for the hydroperoxide-mediated inactivation of prostacyclin synthetase.
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Summary
Hydroxyl radical generation was demonstrated during heme-catalyzed decomposition of 15-hydroperoxy arachidonic acid and the hydroperoxide-mediated inactivation of prostacyclin synthetase seems to be related to the generation of this highly reactive species.
- Type
- article
- Published
- 1979-06-01
- Cited by
- 65
- References
- 7
- Access
- Open access
- OpenAlex
- https://openalex.org/W205396167
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8454139
Keywords
Prostacyclin, Chemistry, Hydroxyl radical, Arachidonic acid, Heme
References
- Reactivity of the Hydroxyl Radical in Aqueous Solutions.
- Evidence for hydroxyl radical generation by human Monocytes.
- Evidence for hydroxyl radical production by human neutrophils.
- Lipid Peroxidation and atherosclerosis
- Intracellular mechanisms for the decomposition of a lipid peroxide. I. Decomposition of a lipid peroxide by metal ions, heme compounds, and nucleophiles.
- The generation of prostacyclin by arteries and by the coronary vascular bed is reduced in experimental atherosclerosis in rabbits.
Cited by
- Peroxide mediated effects of homocysteine on arterial prostacyclin synthesis.
- Pre-eclampsia: physiology and immunological aspects.
- Platelets and atherosclerosis.
- 研究 急性心筋梗塞症におけるprostaglandin I 2 産生促進血漿因子の測定
- Free Radical Reactions in Medicine
- Mechanisms of Heart Failure
- THE EFFECTS OF VITAMIN E ON ARACHIDONIC ACID METABOLISM *
- Mechanisms of the biphasic effects of peroxides on the retinal vasculature of newborn and adult pigs.
- Moderate supplementation with natural alpha-tocopherol decreases platelet aggregation and low-density lipoprotein oxidation.
- Inhibition of tumor cell metastasis by modulation of the vascular prostacyclin/thromboxane A2 system
- The influence of antioxidant nutrients on platelet function in healthy volunteers.
- Marine oils and thrombogenesis.
- Functional consequences of the binding of gliadin to cultured rat mesangial cells: bridging immunoglobulin A to cells and modulation of eicosanoid synthesis and altered cytokine production.
- Activation of prostacyclin synthesis in cultured aortic smooth muscle cells by 'diuretic-antihypertensive' drugs.
- Radical‐scavenging antioxidants in pre‐eclampsia and eclampsia
- Relationship between elevated lipid peroxides, vitamin E deficiency and hypertension in preeclampsia
- Prostacyclin and Thrombotic Microangiopathy
- Hydrogen peroxide stimulates rat colonic prostaglandin production and alters electrolyte transport.
- Role of oxygen-derived free radicals on rat splanchnic eicosanoid production during acute hemorrhage.
- Role of hydrogen peroxide in the neutrophil-mediated release of prostacyclin from cultured endothelial cells.
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