Overproduction of human Cu/Zn‐superoxide dismutase in transfected cells: extenuation of paraquat‐mediated cytotoxicity and enhancement of lipid peroxidation.
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Summary
Human and mouse cell clones that overproduce the hSOD‐1 had altered properties; they were more resistant to paraquat than the parental cells and showed an increase in lipid peroxidation, consistent with the possibility that gene dosage of hS OD‐1 contributes to some of the clinical symptoms associated with Down's syndrome.
- Type
- article
- Published
- 1986-03-01
- Cited by
- 315
- References
- 3
- Access
- Open access
- OpenAlex
- https://openalex.org/W204358047
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25458856
Keywords
Superoxide dismutase, Transfection, Molecular biology, Biology, Paraquat
References
Cited by
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- The importance of antioxidant enzymes in cellular aging and degeneration.
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- Paraquat-resistant HeLa cells.
- Alteration of growth rate and fibronectin by imbalances in superoxide dismutase and glutathione peroxidase activity.
- Superoxide dismutase: pharmacological developments and applications.
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- Elucidating the role of microRNAs in testicular development and spermatogenesis
- Differential proliferative responses of Syrian hamster embryo fibroblasts to paraquat-generated superoxide radicals depending on tumor suppressor gene function.
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