Hydroxyurea as a reference standard in teratological screening. Comparison of the embryotoxic and teratogenic effects following single intraperitoneal or repeated oral administrations to pregnant rats.

Keywords

Medicine, Teratology, Diaphragmatic hernia, Gestation, Oral administration

References

• The effects of hydroxyurea and related compounds on the rat fetus.Shakuntala Chaube, M. Lois Murphy — 1966
• Comparative distribution and embryotoxicity of hydroxyurea in pregnant rats and rhesus monkeys.James Wilson, William J. Scott, Edmond J. Ritter — 1975
• Drug-induced limb dysplasias in fetal rabbits.John M. DeSesso, Robert L. Jordan — 1977
• Relationship of temporal patterns of cell death and development to malformations in the rat limb. Possible mechanisms of teratogenesis with inhibitors of DNA synthesis.Edmond J. Ritter, William J. Scott, James G. Wilson — 1973
• Postnatal effects in rats of prenatal treatment with hydroxyurea.Richard E. Butcher, William J. Scott, Kathy Kazmaier — 1973
• PRELIMINARY SURVEY OF HYDROXYUREA (NSC-32065) AS A TERATOGEN.Murphy Ml, Shakuntala Chaube — 1964
• Teratological studies of p-butoxyphenylacethydroxamic acid (CP 1044 J3) in rats and rabbits.J. Roba, G. Lambelin, Buu-Hoï Np — 1970

Cited by

• Sensitive windows of skeletal development in rabbits determined by hydroxyurea exposure at different times throughout gestation.María Helena da Cruz Coelho — 2012
• Acquired DNA mutations associated with in vivo hydroxyurea exposure.Valerie N. Hanft, Steven R. Fruchtman, Chrisley V. Pickens — 2000
• Guidelines for the Use of Antiretroviral Agents in HIV-Infected Adults and Adolescents, February 5, 2001These Guidelines were developed by the Panel on Clinical Practices for Treatment of HIV Infection convened by the Department of Health and Human Services (DHHS) and the Henry J. Kaiser Family Foundation. Leadership of the Panel consists of Anthony S. Fauci, National Institutes of Health, Bethesda, MD (co-chair); John G. Bartlett, Johns Hopkins University, Baltimore, MD (co-chair); Eric P. Goosby, DHHS, Washington, DC, (co-convener); and Jennifer Kates, Henry J. Kaiser Foundation, San Francisco, — 2001
• Hydroxyurea Induces Site‐specific DNA Damage via Formation of Hydrogen Peroxide and Nitric OxideKatsuhisa Sakano, Shinji Oikawa, Keishi Hasegawa — 2001
• The pharmacotherapy of sickle cell diseaseWinfred C. Wang — 2008
• DNA damage in blood leukocytes of individuals with sickle cell disease treated with hydroxyurea.João Ricardo Friedrisch, Daniel Prá, Sharbel Weidner Maluf — 2008
• Detection of neuroteratogens with an in vitro cytotoxicity assay using primary monolayers cultured from dissociated foetal rat brains.K. S. Khera, C. Whalen — 1988
• Teratologic evaluation of dinitrotoluene in the Fischer 344 rat.Catherine J. Price — 1985
• The inhibition of ribonucleoside diphosphate reductase by hydroxyurea, guanazole and pyrazoloimidazole (IMPY).E. Colleen Moore, Robert B. Hurlbert — 1985
• In vitro and in vivo anti-angiogenic effects of hydroxyurea.Flávia Cristine Mascia Lopes, Regiane Ferreira, Dulcinéia Martins de Albuquerque — 2014
• Length of treatment and dose as determinants of mutagenicity in sickle cell disease patients treated with hydroxyurea.Sharbel Weidner Maluf, Daniel Prá, João Ricardo Friedrisch — 2009
• Cytotoxicity and DNA damage in the neutrophils of patients with sickle cell anaemia treated with hydroxyureaAlano Martins Pedrosa, Maritza Cavalcante Barbosa, Thayna Nogueira dos Santos — 2014
• Teratologic and postnatal evaluation of aniline hydrochloride in the Fischer 344 rat.Catherine J. Price, Rochelle W. Tyl, Thomas A. Marks — 1985
• Pregnancy and its management in the Philadelphia negative myeloproliferative diseasesClaire Harrison — 2005
• Activity profiles of developmental toxicity: design considerations and pilot implementation.Robert J. Kavlock, J.A. Greene, Gary L. Kimmel — 1991
• DNA damage in leukocytes of sickle cell anemia patients is associated with hydroxyurea therapy and with HBB*S haplotype.Lilianne Brito da Silva Rocha, Darcielle Bruna Dias Elias, Maritza Cavalcante Barbosa — 2012
• Interferon and the treatment of polycythemia vera, essential thrombocythemia and myelofibrosisRichard T. Silver, Jean‐Jacques Kiladjian, Hans Carl Hasselbalch — 2013
• NTP-CERHR expert panel report on the reproductive and developmental toxicity of hydroxyurea.Erica L. Liebelt, Sophie J. Balk, Willem D. Faber — 2007
• Antiretroviral treatment of maternal HIV infection.Haleh Talaie, Alejandro A. Nava‐Ocampo, Gideon Koren — 2004
• Response to hydroxyurea treatment in Iranian transfusion-dependent beta-thalassemia patients.Majid Yavarian, Mehran Karimi, Egbert Bakker — 2004

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