Lipophilicity and drug activity.
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Summary
The understanding of drug potency in biological systems requires an understanding of chemical structures in terms of physical and chemical properties.
- Type
- review
- Published
- 1979-01-01
- Cited by
- 69
- References
- 223
- OpenAlex
- https://openalex.org/W194092756
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9263236
Keywords
Lipophilicity, Drug, Chemistry, Pharmacology, Biological activity
References
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- Advances in Linear Free Energy Relationships
- Quantitative structure-activity analysis : proceedings of the 2. Symposium on Chem. Structure-Biolog. Activity Relationships, Quantitative Approaches, Suhl, 1976
- Strategy of drug design: A guide to biological activity
- Molecular connectivity in chemistry and drug research
- Dihydrofolate reductase from Lactobacillus casei. X-ray structure of the enzyme methotrexate.NADPH complex.
- The structure and action of proteins
- The hydrophobic fragmental constant, its derivation and application: A means of characterizing membrane systems
- Substituent constants for correlation analysis in chemistry and biology
- High-pressure liquid chromatography of drugs. An evaluation of an octadecylsilane stationary phase.
- Quantitative Structure-Activity Studies. I. Parameters relating to Hydrophobicity
- Textbook of organic medicinal and pharmaceutical chemistry.
- Structure-activity relationships in immunochemistry--V. The interaction of phenylsuccinamates and pyridine haptens with anti-3-azopyridine antibody.
- Human liver mitochondrial monoamine oxidase. I. Kinetic studies of model interactions.
- International Encyclopedia of Pharmacology and Therapeutics
- Transport of alkyl homologs across synthetic and biological membranes: a new model for chain length-activity relationships.
Cited by
- Ionization-specific analysis of human intestinal absorption.
- Chromatographic Indexes on Immobilized Artificial Membranes for Local Anesthetics: Relationships with Activity Data on Closed Sodium Channels
- 6 A Practical Approach to Computational Models of the Blood-Brain Barrier
- The Determination of Interfacial Transfer Constants Using Side-by-Side Diffusion Cells
- Activity of piperaquine and other 4-aminoquinoline antiplasmodial drugs against chloroquine-sensitive and resistant blood-stages of Plasmodium falciparum. Role of beta-haematin inhibition and drug concentration in vacuolar water- and lipid-phases.
- In vitro characterization of telmisartan-derived compounds for selective peroxisome-proliferator activated receptor gamma (PPARγ) modulation
- Structure-pharmacokinetics relationship of quaternary ammonium compounds
- The expanding role of quantitative structure-activity relationships (QSAR) in toxicology.
- Effects of molecular mass and hydrophobicity on transport rates through non-specific pathways of the silkworm larva midgut.
- Calculation of molecular lipophilicity: state of the art and comparison of methods on more than 96000 compounds
- Lipophilicity as a determinant of binding of procaine analogs to rat α3β4 nicotinic acetylcholine receptor
- Synthesis and structure-activity relationships of antiinflammatory 1-methyl-2-(4-X-benzoyl)imidazole-5-acetic acids
- Thiol-group reactivity, hydrophilicity and stability of alloxan, its reduction products and its N-methyl derivatives and a comparison with ninhydrin.
- Quantitative structure-pharmacokinetic relationships and drug design.
- Shapes of membrane permeability-lipophilicity curves: extension of theoretical models with an aqueous pore pathway.
- Transport rate constants and transport rate parameters in various organic solvent—water systems
- Partitioning and lipophilicity in quantitative structure-activity relationships.
- Review of theoretical passive drug absorption models: historical background, recent developments and limitations.
- Teratogenicity and lethality of hydantoin derivatives in the mouse: structure--toxicity relationships.
- Physicochemical and Biological Data for the Development of Predictive Organophosphorus Pesticide QSARs and PBPK/PD Models for Human Risk Assessment
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