Effects of megakaryocyte growth and development factor on platelet production, platelet life span, and platelet function in healthy human volunteers.
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Summary
The effects of thrombopoietic stimulation on megakaryocytopoiesis, platelet production, and platelet viability and function were examined in normal volunteers randomized to receive single bolus subcutaneous injections of PEG-rHuMGDF or placebo in a 3:1 ratio.
- Type
- article
- Published
- 2000-04-15
- Cited by
- 216
- References
- 60
- OpenAlex
- https://openalex.org/W168471380
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5308495
Keywords
Megakaryocyte, Platelet, Thrombopoietin, Mean platelet volume, Internal medicine
References
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- Guidelines for statistical reporting in articles for medical journals. Amplifications and explanations.
- The use of PEG‐rHuMGDF in platelet apheresis
- Experimental Arterial Thromboembolism in Baboons: Mechanism, Quantitation and Pharmacologic Prevention
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- Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo
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- Human placental anticoagulant protein: isolation and characterization.
Cited by
- Regulation of platelet production: the normal response to perturbation and cyclical platelet disease.
- Cellular lifespan based pharmacodynamic analysis of erythropoiesis
- Distributed transit compartments for arbitrary lifespan distributions in aging populations.
- Mathematical model of radiation effects on thrombopoiesis in rhesus macaques and humans.
- Is darkfield microscopic examination of fresh capillary blood a valid point of care screening to assess metabolic syndrome risk factors
- Review article: pharmacological approaches for the treatment of thrombocytopenia in patients with chronic liver disease and hepatitis C infection
- Primeras administraciones de un nuevo antileucotrieno en humanos: seguridad y farmacocinética. Papel del modelado poblacional en el desarrollo clínico de nuevos compuestos
- Multicenter, prospective study to evaluate the efficacy of biweekly romiplostim administration in patients with immune thrombocytopenia
- Failing to Live Up to the Fanfare? A Personal Perspective on Obstacles to the Clinical Development of Thrombopoietic Agents
- Modeling time variant distributions of cellular lifespans: increases in circulating reticulocyte lifespans following double phlebotomies in sheep
- A rationally designed agonist antibody fragment that functionally mimics thrombopoietin
- Hematopoietic Recovery Following Autologous Bone Marrow Transplantation in a Nonhuman Primate: Effect of Variation in Treatment Schedule with PEG‐rHuMGDF
- BDNF as a biomarker for successful treatment of mood disorders: a systematic & quantitative meta-analysis.
- Mono-N-terminal poly(ethylene glycol)-protein conjugates.
- Platelet count control in immune thrombocytopenic purpura patient: optimum romiplostim dose profile
- The effect of oestrogen on megakaryocyte differentiation and platelet counts in vivo.
- Neutrophil Dynamics in Peritoneal Carcinomatosis Patients Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Oxaliplatin
- Interpretation of transit compartments pharmacodynamic models as lifespan based indirect response models
- Comparative analyses of the small molecule thrombopoietin receptor agonist eltrombopag and thrombopoietin on in vitro platelet function.
- The role of thrombopoietin in post‐operative thrombocytosis
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