A Possible Explanation for the Variable Frequencies of Cancer Stem Cells in Tumors
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Summary
A stochastic model is proposed that is able to capture this potential variability in the frequency of CSCs among the various type of tumors and suggests that traditional attempts to combat cancer cells with rapid cycling can be very stimulating for the cancer stem cell populations.
- Type
- article
- Published
- 2013-08-07
- Cited by
- 11
- References
- 73
- Access
- Open access
- OpenAlex
- https://openalex.org/W161373794
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:18383178
Keywords
Cancer stem cell, Cancer cell, Stem cell, Cancer, Cancer research
References
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- Differential Equations, Dynamical Systems, and an Introduction to Chaos
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- A second course in stochastic processes
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- Tumor Gompertzian growth by cellular energetic balance
- Phenotypic heterogeneity and instability of human ovarian tumor-initiating cells
- Cancer stem cells in solid tumors: elusive or illusive?
- Spontaneous regression of metastases from melanoma: review of the literature
- Cancer stem cells, becoming common
- Harvesting in a random environment: Itô or Stratonovich calculus?
- Regulation of stem cell plasticity: mechanisms and relevance to tissue biology and cancer.
- Bistable kinetic model driven by correlated noises: Steady-state analysis.
- Intra-tumour heterogeneity: a looking glass for cancer?
- Identification of cells initiating human melanomas
Cited by
- The phenotypic equilibrium of cancer cells: From average-level stability to path-wise convergence.
- The overshoot and phenotypic equilibrium in characterizing cancer dynamics of reversible phenotypic plasticity.
- A multi-phenotypic cancer model with cell plasticity.
- Evaluation of circulating cellular DCLK1 protein, as the most promising colorectal cancer stem cell marker, using immunoassay based methods
- Emerging Non-Canonical Functions and Regulation by p53: p53 and Stemness
- 5-Nitrofurans and ALDH: implications for a novel therapeutic approach in cancer
- Epigenetic control of variation and stochasticity in metabolic disease
- The invasion of de-differentiating cancer cells into hierarchical tissues
- Heterogeneous protein dynamics links to mitochondrial activity, glucose transporter, and ALDH cancer stem cell properties
- Heterogeneity of glucose metabolism and uptake identifies distinct cancer cell and cancer stem cell phenotypes
- The invasion of de-differentiating cancer cells into hierarchical tissues
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