Towards a new generation of vaccines: the cytokine IL-12 as an adjuvant to enhance cellular immune responses to pathogens during prime-booster vaccination regimens.
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Summary
Results described here indicate that VV IL-12-mediated enhancement of the specific CMI response against a model antigen HIV-1 env was time- and dose-dependent and that the antigen and the cytokine could be expresed from two different rVVs modulating the doses of the vectors and allowing for enhancement of a specific C MI response.
- Type
- review
- Published
- 2001-04-01
- Cited by
- 44
- References
- 26
- OpenAlex
- https://openalex.org/W160900762
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:31974188
Keywords
Vaccination, Immunology, Immune system, Adjuvant, DNA vaccination
References
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Cited by
- Review of cytokine profiles in patients with hepatitis.
- IL-12: a promising adjuvant for cancer vaccination
- Use of recombinant cytokines for optimized induction of antiviral immunity against SIV in the nonhuman primate model of human AIDS
- Subcutaneous injection of interleukin 12 induces systemic inflammatory responses in humans: implications for the use of IL-12 as vaccine adjuvant
- The use of growth factors and cytokines to treat opportunistic infections in HIV-1 disease.
- Recombinant poxviruses as mucosal vaccine vectors.
- Novel Mucosal DNA-MVA HIV Vaccination in Which DNA-IL-12 Plus Cholera Toxin B Subunit (CTB) Cooperates to Enhance Cellular Systemic and Mucosal Genital Tract Immunity
- Protective effect of a multiantigenic DNA vaccine against Toxoplasma gondii with co‐delivery of IL‐12 in mice
- Antibody regulation of T-cell immunity: implications for vaccine strategies against intracellular pathogens
- Virus-like particles: designing an effective AIDS vaccine.
- Intradermal NKT cell activation during DNA priming in heterologous prime‐boost vaccination enhances T cell responses and protection against Leishmania
- IL-12/GM-CSF Coadministration in an SIV DNA Prime/Protein Boost Protocol Enhances Gag-Specific T Cells But Not Virus-Specific Neutralizing Antibodies in Rhesus Macaques
- Cytokines and HIV-1: Interactions and Clinical Implications
- Molecular adjuvants for mucosal immunity
- From single-dose vaccine delivery systems to nanovaccines
- Day 3 Poly (I:C)-activated dendritic cells generated in CellGro for use in cancer immunotherapy trials are fully comparable to standard Day 5 DCs.
- The cell-mediated immune response induced by plasmid encoding bovine herpesvirus 1 glycoprotein B is enhanced by plasmid encoding IL-12 when delivered intramuscularly or by gene gun, but not after intradermal injection.
- DNA vaccination with linear minimalistic (MIDGE) vectors confers protection against Leishmania major infection in mice.
- Co-delivery of antigen and IL-12 by Venezuelan equine encephalitis virus replicon particles enhances antigen-specific immune responses and anti-tumor effects
- IL‐12p40‐independent induction of protective immunity upon multiple Plasmodium berghei irradiated sporozoite immunizations
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