Over-expression of VEGF in marrow stromal cells promotes angiogenesis in rats with cerebral infarction via the synergistic effects of VEGF and Ang-2
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Summary
In the MCAO rat model transfected with modified MSCs over-expressing VEGF, compared to the MSC transplantation group, the concentration of V EGF was significantly increased in the brain tissue after cerebral infarction, and the synergistic effects of VEGf and Ang-2 may be responsible for the angiogenesis following cerebralinfarction.
- Type
- article
- Published
- 2012-10-01
- Cited by
- 11
- References
- 26
- OpenAlex
- https://openalex.org/W159522523
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:31844292
Keywords
Angiogenesis, Transfection, Stromal cell, Medicine, Cerebral infarction
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Cited by
- Genetic Engineering of Mesenchymal Stem Cells for Regenerative Medicine
- Is the regulation of SIRT1 by miRNA-34a the key to mesenchymal stem cell survival?
- A Comparative Animal Study of Tendon Grafts Healing After Remnant-Preserving Versus Conventional Anterior Cruciate Ligament Reconstruction
- Catgut implantation at acupoints increases the expression of glutamate aspartate transporter and glial glutamate transporter-1 in the brain of rats with spasticity after stroke
- Effects of thymosin β4 on neuronal apoptosis in a rat model of cerebral ischemia-reperfusion injury
- Genetic Modification of Mesenchymal Stem Cells for Neurological Disease Therapy: What Effects Does it Have on Phenotype/Cell Behavior, Determining Their Effectiveness?
- Relationship between serum HIF-1α and VEGF levels and prognosis in patients with acute cerebral infarction combined with cerebral-cardiac syndrome
- Ways to increase the regenerative potential of mesenchymal stromal cells
- Therapeutic gene delivery by mesenchymal stem cell for brain ischemia damage: Focus on molecular mechanisms in ischemic stroke
- Therapeutic Applications of Engineered Mesenchymal Stromal Cells for Enhanced Angiogenesis in Cardiac and Cerebral Ischemia
- Tongqiao huoxue decoction and its components promote angiogenesis and treat ischemic stroke via glycolysis-enhanced VEGF-A/VEGFR2 pathway.
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